N-Acetylcysteine Prevents Deleterious Effects of Ischemia/Reperfusion Injury on Healing of Colonic Anastomosis in Rats

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dc.contributor.authorKabali, B.
dc.contributor.authorGirgin, S.
dc.contributor.authorGedik, E.
dc.contributor.authorOzturk, H.
dc.contributor.authorKale, E.
dc.contributor.authorBuyukbayram, H.
dc.date.accessioned2024-04-24T17:14:27Z
dc.date.available2024-04-24T17:14:27Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study was designed to determine the effects of intraperitoneally or orally administered N-acetylcysteine (NAC) on wound healing following resection and anastomosis of a colon segment with ischemia/reperfusion injury. Forty female Spraque-Dawley rats were randomly allocated to one of four groups containing 10 rats each: (1) normal resection plus anastomosis; (2) ischemia/reperfusion plus resection plus anastomosis; (3) ischemia/reperfusion plus resection plus anastomosis plus intraperitoneal NAC; (4) ischemia/reperfusion plus resection plus anastomosis plus oral NAC. Group comparison showed that the anastomosis bursting pressure was significantly higher in group 3 than in the other groups. The mean tissue hydroxyproline concentration in the anastomotic tissue was significantly lower in group 2 than in the other groups. The collagen deposition was significantly increased on day 7 in groups 3 and 4 compared to the other groups. In conclusion, this study demonstrates that NAC significantly prevents the effects of reperfusion injury on colonic anastomoses in a rat model. Copyright (C) 2009 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000210673
dc.identifier.endpage12en_US
dc.identifier.issn0014-312X
dc.identifier.issn1421-9921
dc.identifier.issue1en_US
dc.identifier.pmid19346747en_US
dc.identifier.scopus2-s2.0-63549126221en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage8en_US
dc.identifier.urihttps://doi.org/10.1159/000210673
dc.identifier.urihttps://hdl.handle.net/11468/17956
dc.identifier.volume43en_US
dc.identifier.wosWOS:000266572500002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofEuropean Surgical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-Acetylcysteineen_US
dc.subjectIschemia/Reperfusion Injuryen_US
dc.subjectColonic Anastomosisen_US
dc.subjectRaten_US
dc.titleN-Acetylcysteine Prevents Deleterious Effects of Ischemia/Reperfusion Injury on Healing of Colonic Anastomosis in Ratsen_US
dc.typeArticleen_US

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