Protective role of caffeic acid phenethyl ester on serum cholinesterase inhibition by acute exposure to diazinon in rats

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dc.contributor.authorOguzhanoglu, Esin
dc.contributor.authorAndac, Ahmet Cenk
dc.contributor.authorTufek, Adnan
dc.contributor.authorYavuz, Lutfi
dc.contributor.authorVural, Huseyin
dc.contributor.authorGokalp, Osman
dc.date.accessioned2024-04-24T17:21:08Z
dc.date.available2024-04-24T17:21:08Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: To evaluate whether caffeic acid phenethyl ester (CAPE), a flavonoid-like natural compound plentifully found in beeswax, has a protective effect on diazinon-induced serum cholinesterase (ChE) inhibition in rats. Materials and methods: Animals were divided into 4 groups. The first animal group was not treated with any substance. The second animal group was orally given a 200 mg/kg body weight (bw) sublethal dose of diazinon. The third animal group was injected intraperitoneally with 2.84 mg (10 mu mol)/kg bw of CAPE 1 day prior to administration of 200 mg/kg bw of diazinon orally. The fourth animal group was intraperitoneally injected with 2.84 mg (10 mu mol)/kg bw of CAPE 30 min after 200 mg/kg bw of diazinon was orally administered. Results: Analysis of the animal blood samples obtained 48 h after diazinon administration revealed that diazinon decreased serum ChE activity by 75%, while CAPE administration 24 h prior to and 30 min following diazinon application improved serum ChE activity by 25%-32% as compared to levels with diazinon administration only. In silico studies suggest that CAPE prevents diazinon from binding to butyryl ChE due to a higher binding affinity than that of diazinon. Conclusion: Our laboratory findings suggest that CAPE plays a protective role against butyryl ChE inhibition by diazinon.en_US
dc.description.sponsorshipScientific Research Foundation (BAP) at Suleyman Demirel University, Isparta, Turkey [1777-TU-09]en_US
dc.description.sponsorshipWe would like to thank the TR-Grid e-Infrastructure of Turkey for allowing us to use the computational facility therein. This work was funded by the Scientific Research Foundation (BAP) at Suleyman Demirel University, Isparta, Turkey, Grant No. 1777-TU-09.en_US
dc.identifier.doi10.3906/sag-1210-46
dc.identifier.endpage120en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.pmid25558570
dc.identifier.startpage115en_US
dc.identifier.trdizinid213029
dc.identifier.urihttps://doi.org/10.3906/sag-1210-46
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/213029
dc.identifier.urihttps://hdl.handle.net/11468/19383
dc.identifier.volume44en_US
dc.identifier.wosWOS:000327592600020
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOrganophosphateen_US
dc.subjectDiazinonen_US
dc.subjectCaffeic Acid Phenethyl Esteren_US
dc.subjectSerum Cholinesteraseen_US
dc.subjectDockingen_US
dc.titleProtective role of caffeic acid phenethyl ester on serum cholinesterase inhibition by acute exposure to diazinon in ratsen_US
dc.titleProtective role of caffeic acid phenethyl ester on serum cholinesterase inhibition by acute exposure to diazinon in rats
dc.typeArticleen_US

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