Effects of intralipid and caffeic acid phenethyl ester on neurotoxicity, oxidative stress, and acetylcholinesterase activity in acute chlorpyriphos intoxication

Basit Öğe Kaydı
dc.contributor.authorOzkan, Umit
dc.contributor.authorOsun, Arif
dc.contributor.authorBasarslan, Kagan
dc.contributor.authorSenol, Serkan
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorAlp, Harun
dc.date.accessioned2024-04-24T17:33:41Z
dc.date.available2024-04-24T17:33:41Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractChlorpyriphos is one of the most widely used organophosphate (OP) insecticide in agriculture with potential toxicity. Current post-exposure treatments consist of anti-cholinergic drugs and oxime compounds. We studied the effects of intralipid and caffeic acid phenethyl ester (CAPE) on chlorpyriphos toxicity to compose an alternative or supportive treatment for OP poisoning. Methods: Forty-nine rats were randomly divided into seven groups. Chlorpyriphos was administered for toxicity. Intralipid (IL) and CAPE administered immediately after chlorpyriphos. Serum acetylcholinesterase (AChE) level, total oxidant status (TOS), total antioxidant response (TAR), and histologic examination of cerebellum and brain tissue with Hematoxylin-Eosin and immunohistochemical dyes were examined. Results: Serum enzym levels showed that chlorpyriphos and CAPE inhibited AChE while IL alone had no effect, chlorpyriphos and CAPE intensifies the inhibition effect. Significant difference at AChE levels between the chlorpyriphos+IL and chlorpyriphos+CAPE verified that IL has a protective effect on AChE inhibition. TAR levels were significantly increased in all groups except chlorpyriphos group, TOS levels revealed that CAPE and IL decrease the amount of oxidative stress. Histologic examination revealed that neuronal degeneration was slightly decreased at chlorpyriphos+IL group, but CAPE had a significant effect on protection of neuronal degeneration. Conclusion: The results of this study gave us three key points. 1) AChE activity is important for diagnosis of OP intoxication but it has no value for determining the neuro-degeneration. 2) CAPE inhibits AChE activity and may increase the muscarinic-nicotinic hyperactivation. Therefore it should not be used for treatment of OP intoxication. 3) IL decreases the severity of neurodegeneration and symptoms of OP intoxication and it can be used as a supportive agent.en_US
dc.description.sponsorshipMustafa Kemal University [1206M0122]en_US
dc.description.sponsorshipThis study with 1206M0122 ID number was supported by Mustafa Kemal University Scientific Research Project Coordination.en_US
dc.identifier.endpage846en_US
dc.identifier.issn1940-5901
dc.identifier.issue4en_US
dc.identifier.pmid24955152
dc.identifier.scopus2-s2.0-84900459338
dc.identifier.scopusqualityN/A
dc.identifier.startpage837en_US
dc.identifier.urihttps://hdl.handle.net/11468/20805
dc.identifier.volume7en_US
dc.identifier.wosWOS:000336740600005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChlorpyriphosen_US
dc.subjectIntralipiden_US
dc.subjectCapeen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectNeurotoxicityen_US
dc.titleEffects of intralipid and caffeic acid phenethyl ester on neurotoxicity, oxidative stress, and acetylcholinesterase activity in acute chlorpyriphos intoxicationen_US
dc.titleEffects of intralipid and caffeic acid phenethyl ester on neurotoxicity, oxidative stress, and acetylcholinesterase activity in acute chlorpyriphos intoxication
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu