Serum levels of carcinoembryonic antigen (CEA) in patients with bipolar disorder

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dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorBulut, Mahmut
dc.contributor.authorAtli, Abdullah
dc.contributor.authorGunes, Mehmet
dc.contributor.authorKaya, Mehmet Cemal
dc.contributor.authorColpan, Leyla
dc.date.accessioned2024-04-24T16:19:01Z
dc.date.available2024-04-24T16:19:01Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective Carcinoembryonic antigen (CEA) is an oncofetal glycoprotein that is widely used as a tumour marker in adenocarcinomas. However, several non-neoplastic conditions, including acute and chronic inflammation and other inflammation-related conditions, are characterised by increased CEA concentrations. Bipolar disorder (BD) ranks seventh among the worldwide burden of non-fatal diseases. Inflammatory biomarkers have been considered as one of the main key pillars of a multifactorial approach for prediction of BD in an at-risk population. BP is accompanied by activation of inflammatory, cell-mediated and negative immunoregulatory cytokines. Methods We measured the levels of CEA in serum samples from 44 individuals with euthymic BP out-patients and 45 healthy controls. Patients were diagnosed according to the DSM-IV criteria. CEA was measured by an electrochemiluminescence immunoassay. Results The mean serum CEA concentration was 2.361.52 and 1.77 +/- 0.98 mu g/l in patients and controls, respectively. CEA levels were significantly increased in euthymic BP patients when compared with controls (p=0.031). Conclusions This study suggests that CEA is increased in BD and supports a role for immune activation in the core pathological mechanisms of BP. CEA levels may be a secondary marker for diagnosing BP.en_US
dc.identifier.doi10.1017/neu.2015.5
dc.identifier.endpage181en_US
dc.identifier.issn1601-5215
dc.identifier.issue3en_US
dc.identifier.pmid25697175
dc.identifier.scopus2-s2.0-84929284329
dc.identifier.scopusqualityQ1
dc.identifier.startpage177en_US
dc.identifier.urihttps://doi.org/10.1017/neu.2015.5
dc.identifier.urihttps://hdl.handle.net/11468/16374
dc.identifier.volume27en_US
dc.identifier.wosWOS:000354391600006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofActa Neuropsychiatrica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBipolar Disorderen_US
dc.subjectCeaen_US
dc.subjectProinflammatory Cytokinesen_US
dc.titleSerum levels of carcinoembryonic antigen (CEA) in patients with bipolar disorderen_US
dc.titleSerum levels of carcinoembryonic antigen (CEA) in patients with bipolar disorder
dc.typeArticleen_US

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