Evaluation of parafoveal and peripapillary vascular densities using optical coherence tomography angiography in children with thalassemia major

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dc.authorid0000-0003-3346-3290en_US
dc.authorid0000-0002-8206-781Xen_US
dc.authorid0000-0002-3591-721Xen_US
dc.authorid0000-0001-5742-1293en_US
dc.authorid0000-0001-8856-0528en_US
dc.authorid0000-0002-3037-2353en_US
dc.authorid0000-0003-2348-4856en_US
dc.contributor.authorDursun, Mehmet Emin
dc.contributor.authorHazar, Leyla
dc.contributor.authorKarahan, Mine
dc.contributor.authorErdem, Seyfettin
dc.contributor.authorAva, Sedat
dc.contributor.authorÜzel, Veysiye Hülya
dc.contributor.authorDursun, Birgül
dc.contributor.authorKeklikçi, Uğur
dc.date.accessioned2023-10-05T12:16:13Z
dc.date.available2023-10-05T12:16:13Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractBackground: Thalassemia major (TM) is an inherited anaemia caused by faulty haemoglobin synthesis. Reducing serum iron levels using iron chelating agents is an important step in the treatment of TM, and the effects on the eye of both the disease and these agents can be determined by regular eye examination. Objectives: We evaluated macular and optic nerve vascular densities in children with TM and compared the results with healthy controls using optical coherence tomography angiography (OCTA). Design: This is a prospective study. Methods: A total of 30 children with TM and 30 healthy controls were included in the study. The area of the foveal avascular zone (FAZ) and the vascular densities (VD) of the optic nerve head (ONH), radial peripapillary capillary (RPC) and deep and superficial retinal vascular networks were measured using OCTA. Results: A statistically significant decrease in VD was observed in the whole image and the parafovea, superior hemi, superior and inferior parts of the superficial capillary plexus and in the whole image and the superior regions of the deep capillary plexus in the TM patient group compared with the control group (p < 0.05). A significant decrease in VD was also observed in the whole image and the inside disc, peripapillary, nasal, inferonasal and temporal regions of the ONH and in the whole image and the inside disc, peripapillary and inferonasal regions of the RPC network in patients with TM (p < 0.05). A significant positive correlation was observed between both serum ferritin levels and deferasirox dosage, on one hand, and both the superficial (p = 0.023 and p = 0.002, respectively) and deep FAZs (p = 0.015 and p = 0.045, respectively), on the other hand. A negative correlation was also found between the deferasirox dosage and the VDs of the superficial (p = 0.010) and deep (p = 0.001) foveal plexuses. Conclusion: Retinal VD and FAZ are affected in patients with TM. OCTA, which can noninvasively measure retinal VD in patients with TM, may be a useful tool for the early detection of retinal microvascular changes that may occur during the course of the disease.en_US
dc.identifier.citationDursun, M. E., Hazar, L., Karahan, M., Erdem, S. Ava, S., Üzel, V. H. ve diğerleri. (2023). Evaluation of parafoveal and peripapillary vascular densities using optical coherence tomography angiography in children with thalassemia major. Therapeutic Advances in Ophthalmology, (15), 1-10.en_US
dc.identifier.doi10.1177/25158414231162846
dc.identifier.endpage10en_US
dc.identifier.issn2515-8414
dc.identifier.issue15en_US
dc.identifier.pmid37056915
dc.identifier.scopus2-s2.0-85152087630
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://journals.sagepub.com/doi/epub/10.1177/25158414231162846
dc.identifier.urihttps://hdl.handle.net/11468/12749
dc.identifier.wosWOS:000962785000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDursun, Mehmet Emin
dc.institutionauthorHazar, Leyla
dc.institutionauthorKarahan, Mine
dc.institutionauthorErdem, Seyfettin
dc.institutionauthorAva, Sedat
dc.institutionauthorÜzel, Veysiye Hülya
dc.institutionauthorKeklikçi, Uğur
dc.language.isoenen_US
dc.publisherSAGE Publications Ltd.en_US
dc.relation.ispartofTherapeutic Advances in Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCapillary plexusen_US
dc.subjectFoveal avascular zoneen_US
dc.subjectOptical coherence tomography angiographyen_US
dc.subjectThalassemiaen_US
dc.subjectVascular densityen_US
dc.titleEvaluation of parafoveal and peripapillary vascular densities using optical coherence tomography angiography in children with thalassemia majoren_US
dc.titleEvaluation of parafoveal and peripapillary vascular densities using optical coherence tomography angiography in children with thalassemia major
dc.typeArticleen_US

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