Protective effects of Rosmarinic acid against renal ischaemia/reperfusion injury in rats

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dc.contributor.authorOzturk, Hulya
dc.contributor.authorOzturk, Hayrettin
dc.contributor.authorTerzi, Elcin Hakan
dc.contributor.authorOzgen, Ufuk
dc.contributor.authorDuran, Arif
dc.contributor.authorUygun, Ibrahim
dc.date.accessioned2024-04-24T17:37:52Z
dc.date.available2024-04-24T17:37:52Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: To investigate the potential protective effects of Rosmarinic acid (RA) on rats exposed to ischaemia/reperfusion renal injury. Methods: The prospective study was conducted at Abant Izzet Baysal University, Turkey, and comprised 21 male Sprague Dawley rats weighing 250-270g each. They were divided into three equal groups. Unilaterally nephrectomised rats were subjected to 60 minutes of left renal ischaemia followed by 60 minutes of reperfusion. Group 1 had sham-operated animals; group 2 had ischaemia/reperfusion untreated animals; and group 3 had ischaemia/reperfusion animals treated with rosmarinic acid. Serum creatinine, blood urea nitrogen, tissue malondialdehyde, glutathione peroxidase, superoxide dismutase and myeloperoxidase (MPO) activities, and light microscopic findings were evaluated. SPSS 17 was used for statistical analysis. Results: Treatment of rats with rosmarinic acid produced a reduction in the serum levels of creatinine and blood urea nitrogen compared to the other groups. However, no statistically significant difference was found. The levels of malondialdehyde and myeloperoxidase were decreased in the renal tissue of group 3, while glutathione peroxidose and superoxide dismutase levels remained unchanged. The injury score decreased in the treatment group rats compared to the untreated group. Rosmarinic acid significantly decreased focal glomerular necrosis, dilatation of Bowman's capsule, degeneration of tubular epithelium, necrosis in tubular epithelium, and tubular dilatation. Conclusions: Rosmarinic acid prevented ischaemia/reperfusion injury in the kidneys by decreasing oxidative stress.en_US
dc.identifier.endpage265en_US
dc.identifier.issn0030-9982
dc.identifier.issue3en_US
dc.identifier.pmid24864596
dc.identifier.scopus2-s2.0-84894518834
dc.identifier.scopusqualityQ3
dc.identifier.startpage260en_US
dc.identifier.urihttps://hdl.handle.net/11468/21225
dc.identifier.volume64en_US
dc.identifier.wosWOS:000331780100006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPakistan Medical Assocen_US
dc.relation.ispartofJournal of The Pakistan Medical Association
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRaten_US
dc.subjectRenal/Kidneyen_US
dc.subjectIschaemia/Reperfusion Injuryen_US
dc.subjectRosmarinic Aciden_US
dc.titleProtective effects of Rosmarinic acid against renal ischaemia/reperfusion injury in ratsen_US
dc.titleProtective effects of Rosmarinic acid against renal ischaemia/reperfusion injury in rats
dc.typeArticleen_US

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