Prothrombin G20210A gene mutation with LightCycler polymerase chain reaction in venous thrombosis and healthy population in the southeast of Turkey

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dc.contributor.authorAyyildiz, O
dc.contributor.authorKalkanli, S
dc.contributor.authorBatun, S
dc.contributor.authorAybak, M
dc.contributor.authorIsikdogan, A
dc.contributor.authorTiftik, N
dc.contributor.authorBolaman, Z
dc.date.accessioned2024-04-24T16:00:09Z
dc.date.available2024-04-24T16:00:09Z
dc.date.issued2004
dc.departmentDicle Üniversitesien_US
dc.description.abstractVenous thrombosis (VT) is a common disease, with an annual incidence in the general population of approximately 1 per 1000. The prevalence of genetic risk factors for thrombosis varies greatly in different parts of the world. Prothrombin G20210A (PT G20210A) gene mutation has been recently identified as a common risk factor in venous thrombosis. Sixty-one patients with VT, differing in age and sex, and 340 healthy subjects were consecutively enrolled into our study to determine the prevalence of PT G20210A in VT and in the healthy population of the southeast of Turkey. The mutation was identified with fluorescence resonance energy transfer (FRET) with the LightCycler polymerase chain reaction. The PT G20210A mutation was found to be 6.5% (4/61) in the VT group and 1.2% (4/340) in the healthy group (P = 0.021). Three patients with VT had a heterozygous PT G20210A mutation, and the other patient with VT had both Factor V Leiden and PT G20210A mutations. We showed that this method may be used safely for detection of the PT G20210A gene mutation, and the prevalence of PT G20210A mutation is significantly higher in patients with VT than in the healthy population in the southeast of Turkey.en_US
dc.identifier.doi10.1007/s00380-003-0760-6
dc.identifier.endpage166en_US
dc.identifier.issn0910-8327
dc.identifier.issn1615-2573
dc.identifier.issue4en_US
dc.identifier.pmid15278388
dc.identifier.scopus2-s2.0-4344685226
dc.identifier.scopusqualityQ3
dc.identifier.startpage164en_US
dc.identifier.urihttps://doi.org/10.1007/s00380-003-0760-6
dc.identifier.urihttps://hdl.handle.net/11468/14386
dc.identifier.volume19en_US
dc.identifier.wosWOS:000222864700002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofHeart and Vessels
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProthrombin G20210a Gene Mutationen_US
dc.subjectVenous Thrombosisen_US
dc.subjectLightcycler Polymerase Chain Reactionen_US
dc.titleProthrombin G20210A gene mutation with LightCycler polymerase chain reaction in venous thrombosis and healthy population in the southeast of Turkeyen_US
dc.titleProthrombin G20210A gene mutation with LightCycler polymerase chain reaction in venous thrombosis and healthy population in the southeast of Turkey
dc.typeArticleen_US

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