Outcome of non-metastatic male breast cancer: 118 patients

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dc.contributor.authorArslan, Ulku Yalcintas
dc.contributor.authorOksuzoglu, Berna
dc.contributor.authorOzdemir, Nuriye
dc.contributor.authorAksoy, Sercan
dc.contributor.authorAlkis, Necati
dc.contributor.authorGok, Ayse
dc.contributor.authorKaplan, Mehmet Ali
dc.date.accessioned2024-04-24T16:02:40Z
dc.date.available2024-04-24T16:02:40Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractStudies concerning adjuvant systemic therapy and prognosis in male breast carcinoma (MBC) are limited. We aimed to evaluate outcome of the changing practices of adjuvant systemic treatment and survival in operable MBC patients over the last two decades. The medical records of 148 MBC patients followed between the years 1986 and 2009 at 7 cancer center were evaluated retrospectively. One hundred and eighteen operable non-metastatic patients had sufficient data were included the study. One hundred and eighteen operable MBC were found to be eligible. Median age was 60 (range 29-83) years. Thirty-two percent of the patients had T3-4 tumors. Half of the patients had axillary lymph node-positive disease. The proportion of positivity of estrogen receptor(ER), progesterone receptor (PgR), and HER2 status were 82.9, 75.8, and 23.4%, respectively. Only, 7 patients had triple negative (TN). Adjuvant hormonotherapy was advised for 76.8% whereas adjuvant chemotherapy for 73.7% of the patients. Median follow-up was 40.9 months (range 3.8-186 months). Locoregional and/or distant recurrence developed in thirty-eight patients (32.2%). Twenty-three patients died during the follow-up period. Five-year disease-free survival (DFS) was found to be 60%, whereas overall survival (OS) was 82%. Larger tumor size and lymph node positivity were statistically significant poor prognostic factors for OS. Although statistical insignificant, patients with HER2-positive tumors have worse DFS (52 vs. 120 months, log rank P = .73) and OS (85 vs. 144 months, log rank P = .30) than HER2-negative ones. Although the frequency of the use of adjuvant systemic therapy in MBC has been increasing and survival rates improving for the last decades, lymph node status and tumor size are still the most important determining factors for prognosis. There is a need for further prognostic information in men with HER2-positive or TN breast cancer.en_US
dc.identifier.doi10.1007/s12032-011-9978-9
dc.identifier.endpage560en_US
dc.identifier.issn1357-0560
dc.identifier.issn1559-131X
dc.identifier.issue2en_US
dc.identifier.pmid21573973
dc.identifier.scopus2-s2.0-84866305354
dc.identifier.scopusqualityQ2
dc.identifier.startpage554en_US
dc.identifier.urihttps://doi.org/10.1007/s12032-011-9978-9
dc.identifier.urihttps://hdl.handle.net/11468/14875
dc.identifier.volume29en_US
dc.identifier.wosWOS:000303539000025
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofMedical Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMale Breast Carcinomaen_US
dc.subjectAdjuvanten_US
dc.subjectSurvivalen_US
dc.titleOutcome of non-metastatic male breast cancer: 118 patientsen_US
dc.titleOutcome of non-metastatic male breast cancer: 118 patients
dc.typeArticleen_US

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