The protective effects of pomegranate on liver and remote organs caused by experimental obstructive jaundice model

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dc.contributor.authorYilmaz, E. E.
dc.contributor.authorArikanoglu, Z.
dc.contributor.authorTurkoglu, A.
dc.contributor.authorKilic, E.
dc.contributor.authorYuksel, H.
dc.contributor.authorGumus, M.
dc.date.accessioned2024-04-24T17:39:57Z
dc.date.available2024-04-24T17:39:57Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: We aimed to investigate the protective potential of pomegranate extract on the liver and remote organs in rats with obstructive jaundice. MATERIALS AND METHODS: The rats were split into 4 groups. In Group 1 (G1) (sham group) rats, the common bile duct was mobilized without any ligation. Group 2 (G2) received a combination of the sham operation and synchronous treatment with pomegranate. Group 3 (G3) received common bile duct ligation (CBDL). Group 4 (G4) were subjected to CBDL and treatment with pomegranate. After 8 days, we measured total oxidative status (TOS) and antioxidant capacity in the rats' liver tissue and remote organs, and evaluated blood levels of malondialdehyde and total antioxidant capacity (TAC). RESULTS: G3 rats showed significantly raised malondialdehyde level as compared to G1 rats (p < 0.001). Following the pomegranate therapy, a decrease in malondialdehyde was observed (p = 0.015). TAC levels were significantly raised in the G3 rats compared to the G1 rats (p = 0.004). TAC levels dropped after pomegranate therapy (p = 0.011). CBDL caused elevated TOS levels in the liver and remote organs, with a statistically significant increase in the lung tissue (p = 0.002). TOS levels in the CBDL groups decreased after pomegranate treatment (p < 0.001). CONCLUSIONS: This study reveals the marked protective effect of pomegranate on the liver and remote organs in obstructive jaundice.en_US
dc.identifier.endpage772en_US
dc.identifier.issn1128-3602
dc.identifier.issue4en_US
dc.identifier.pmid26957283
dc.identifier.scopus2-s2.0-85017155132
dc.identifier.scopusqualityQ2
dc.identifier.startpage767en_US
dc.identifier.urihttps://hdl.handle.net/11468/21465
dc.identifier.volume20en_US
dc.identifier.wosWOS:000373349200028
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPomegranateen_US
dc.subjectObstructive Jaundiceen_US
dc.subjectRemote Organen_US
dc.subjectOxidative Stressen_US
dc.titleThe protective effects of pomegranate on liver and remote organs caused by experimental obstructive jaundice modelen_US
dc.titleThe protective effects of pomegranate on liver and remote organs caused by experimental obstructive jaundice model
dc.typeArticleen_US

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