Apparently low serum asymmetric dimethylarginine is associated with fasting glucose and tends toward association with type-2 diabetes

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dc.contributor.authorOnat, Altan
dc.contributor.authorKoroglu, Bayram
dc.contributor.authorCan, Gunay
dc.contributor.authorKaragoz, Ahmet
dc.contributor.authorYuksel, Murat
dc.contributor.authorAydin, Mesut
dc.date.accessioned2024-04-24T17:25:02Z
dc.date.available2024-04-24T17:25:02Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: We investigated the association of serum asymmetric dimethylarginine (ADMA) with metabolic syndrome (MetS), type-2 diabetes and coronary heart disease (CHD) in the general population. Methods: Cross-sectional and, at 2000 person-years' follow-up, prospective analysis. Adults with measured serum ADMA level (n=848) were analyzed using tertiles or dichotomized values. ADMA concentrations were measured by a validated commercial ELISA kit. Results: Dichotomized subjects of combined sexes with low (<= 0.68 mu ol/L) ADMA values had significantly higher fasting glucose, total cholesterol, apolipoprotein B and lower diastolic blood pressure. In linear regression analyses comprising age, smoking, triglyceride, HDL-cholesterol, C-reactive protein and waist circumference as well, creatinine was significantly and independently associated with ADMA, further in women glucose (inversely). In logistic regression analyses uniformly adjusted for age, smoking status and waist girth, prevalent MetS tended to positive independent association with ADMA tertiles only in men. Combined prevalent and incident diabetes weakly tended to be associated with the lowest (vs mid-and highest) ADMA tertiles in combined gender; and prevalent and incident CHD was not associated with ADMA tertiles in either sex. Conclusion: Apparently low circulating ADMA is independently associated with fasting glucose and tends to be so with type-2 diabetes. The lack of anticipated positive associations of ADMA with cardiometabolic disorders is likely due to autoimmune responses operating against serum ADMA under oxidative stress, rendering partial failure in immunoassay.en_US
dc.description.sponsorshipTurkish Adult Risk Factor surveys by the Turkish Society of Cardiologyen_US
dc.description.sponsorshipWe are grateful for the financial support of the Turkish Adult Risk Factor surveys over the years by the Turkish Society of Cardiology, and the various pharmaceutical companies in Istanbul.en_US
dc.identifier.doi10.5152/akd.2013.5009
dc.identifier.endpage33en_US
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue1en_US
dc.identifier.pmid24342929
dc.identifier.scopus2-s2.0-84894564237
dc.identifier.scopusqualityQ3
dc.identifier.startpage26en_US
dc.identifier.urihttps://doi.org/10.5152/akd.2013.5009
dc.identifier.urihttps://hdl.handle.net/11468/19916
dc.identifier.volume14en_US
dc.identifier.wosWOS:000338105200009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTurkish Soc Cardiologyen_US
dc.relation.ispartofAnatolian Journal of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsymmetric Dimethylarginineen_US
dc.subjectDiabetes Type-2en_US
dc.subjectGlucoseen_US
dc.subjectOxidative Stressen_US
dc.subjectSex Differenceen_US
dc.subjectRegression Analysisen_US
dc.titleApparently low serum asymmetric dimethylarginine is associated with fasting glucose and tends toward association with type-2 diabetesen_US
dc.titleApparently low serum asymmetric dimethylarginine is associated with fasting glucose and tends toward association with type-2 diabetes
dc.typeArticleen_US

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