Effects of N-acetylcysteine on pulmonary function in patients undergoing coronary artery bypass surgery with cardiopulmonary bypass

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dc.contributor.authorEren, N
dc.contributor.authorÇakir, Ö
dc.contributor.authorOruc, A
dc.contributor.authorKaya, Z
dc.contributor.authorErdinc, L
dc.date.accessioned2024-04-24T17:14:56Z
dc.date.available2024-04-24T17:14:56Z
dc.date.issued2003
dc.departmentDicle Üniversitesien_US
dc.description.abstractCardiopulmonary bypass (CPB) has been implicated in causing poor pulmonary gas exchange postoperatively in patients undergoing coronary artery bypass grafting (CABG) procedures. In this prospective, randomized, double-blind, placebo-controlled study, we examined the pulmonary effects of N-acetylcysteine (NAC) in patients undergoing CABG. Twenty patients undergoing elective CABG and early tracheal extubation were randomized into two groups. Group I (ten patients) received a physiologic salt solution as a placebo in a continuous intravenous infusion for one hour before CPB and 24 hours after CPB; Group II (ten patients) received 100 mg/ kg NAC intravenously for one hour before CPB and 40 mg/kg/day at 24 hours after CPB. Perioperative hemodynamic and pulmonary data were recorded. Postoperative tracheal extubation was accomplished at the earliest appropriate time. The postoperative clinical course was similar in the two groups. Both groups exhibited significant postoperative increases in A-a oxygen gradient (p < 0.01), but patients in Group II exhibited significantly lower increases in postoperative A-a oxygen gradient (p < 0.006). Other hemodynamic and pulmonary data (pulmonary capillary wedge pressure, pulmonary vascular resistance (PVR), cardiac index (CI), shunt flow, dynamic lung compliance and static lung compliance) exhibited no differences between the groups. There was no significant difference in terms of intubation time. The malondialdehyde (MDA) increase in Group II following CPB was found to be significantly lower than in Group I (p = 0.043). This clinical study reveals that administration of NAC to patients undergoing elective CABG with CPB improves systemic oxygenation. There was no effect in other pulmonary parameters and in terms of intubation time.en_US
dc.identifier.doi10.1191/0267659103pf696oa
dc.identifier.endpage350en_US
dc.identifier.issn0267-6591
dc.identifier.issn1477-111X
dc.identifier.issue6en_US
dc.identifier.pmid14714769
dc.identifier.scopus2-s2.0-0346656763
dc.identifier.scopusqualityQ1
dc.identifier.startpage345en_US
dc.identifier.urihttps://doi.org/10.1191/0267659103pf696oa
dc.identifier.urihttps://hdl.handle.net/11468/18264
dc.identifier.volume18en_US
dc.identifier.wosWOS:000187925900003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofPerfusion-Uk
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleEffects of N-acetylcysteine on pulmonary function in patients undergoing coronary artery bypass surgery with cardiopulmonary bypassen_US
dc.titleEffects of N-acetylcysteine on pulmonary function in patients undergoing coronary artery bypass surgery with cardiopulmonary bypass
dc.typeArticleen_US

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