A Comparison of the Effects of Epidural and Spinal Anesthesia With Ischemia-Reperfusion Injury on the Rat Transverse Rectus Abdominis Musculocutaneous Flap

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dc.contributor.authorAcar, Yusuf
dc.contributor.authorBozkurt, Mehmet
dc.contributor.authorFirat, Ugur
dc.contributor.authorSelcuk, Caferi Tayyar
dc.contributor.authorKapi, Emin
dc.contributor.authorIsik, Fatma Birgul
dc.contributor.authorKuvat, Samet Vasfi
dc.date.accessioned2024-04-24T17:08:28Z
dc.date.available2024-04-24T17:08:28Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe purpose of this study is to compare the effects of spinal and epidural anesthesia on a rat transverse rectus abdominus myocutaneous flap ischemia-reperfusion injury model. Forty Sprague-Dawley rats were divided into 4 experimental groups: group I (n = 10), sham group; group II (n = 10), control group; group III (n = 10), epidural group; and group IV (n = 10), spinal group. After the elevation of the transverse rectus abdominus myocutaneous flaps, all groups except for the sham group were subjected to normothermic no-flow ischemia for 4 hours, followed by a reperfusion period of 2 hours. At the end of the reperfusion period, biochemical and histopathological evaluations were performed on tissue samples. Although there was no significant difference concerning the malonyldialdehyde, nitric oxide, and paraoxonase levels in the spinal and epidural groups, the total antioxidant state levels were significantly increased, and the total oxidative stress levels were significantly decreased in the epidural group in comparison to the spinal group. The pathological evaluation showed that findings related to inflammation, nuclear change rates and hyalinization were significantly higher in the spinal group compared with the epidural group. Epidural anesthesia can be considered as a more suitable method that enables a decrease in ischemia-reperfusion injuries in the muscle flaps.en_US
dc.identifier.doi10.1097/SAP.0b013e31824f220e
dc.identifier.endpage609en_US
dc.identifier.issn0148-7043
dc.identifier.issn1536-3708
dc.identifier.issue5en_US
dc.identifier.pmid23187711
dc.identifier.scopus2-s2.0-84886090755
dc.identifier.scopusqualityQ2
dc.identifier.startpage605en_US
dc.identifier.urihttps://doi.org/10.1097/SAP.0b013e31824f220e
dc.identifier.urihttps://hdl.handle.net/11468/17352
dc.identifier.volume71en_US
dc.identifier.wosWOS:000330457300037
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAnnals of Plastic Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpidural Anesthesiaen_US
dc.subjectSpinal Anesthesiaen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectTransverse Rectus Abdominis Musculocutaneous Flapen_US
dc.titleA Comparison of the Effects of Epidural and Spinal Anesthesia With Ischemia-Reperfusion Injury on the Rat Transverse Rectus Abdominis Musculocutaneous Flapen_US
dc.titleA Comparison of the Effects of Epidural and Spinal Anesthesia With Ischemia-Reperfusion Injury on the Rat Transverse Rectus Abdominis Musculocutaneous Flap
dc.typeArticleen_US

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