Oxidative stress and the importance of H. pylori eradication in patients with functional dyspepsia

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dc.authorid0000-0001-5302-8953en_US
dc.authorid0000-0002-2996-3236en_US
dc.authorid0000-0002-2677-3971en_US
dc.authorid0000-0001-8321-4829en_US
dc.authorid0000-0002-2996-3236en_US
dc.contributor.authorEbik, Berat
dc.contributor.authorAslan, Nihat
dc.contributor.authorEkin, Nazım
dc.contributor.authorBacaksız, Ferhat
dc.contributor.authorArpa, Medeni
dc.contributor.authorNeşelioǧlu, Salim
dc.contributor.authorErel, Özcan
dc.contributor.authorUçmak, Feyzullah
dc.date.accessioned2024-03-01T08:34:52Z
dc.date.available2024-03-01T08:34:52Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractBackground: To investigage the thiol and disulphide levels in Helicobacter pylori-positive patients with non-ulcer dyspepsia and investigate the change in these levels with eradication therapy. Methods: This is a prospective observational study. A total of 320 patients diagnosed with dyspepsia according to Rome IV criteria were included in the study. First, blood samples were drawn from patients to determine their serum thiol and disulphide levels. Endoscopic biopsy was performed on all patients and the biopsy specimens obtained were examined pathologically. Patients positive for H. pylori were administered eradication therapy. Blood samples were drawn from these patients for the second time, and their serum thiol and disulphide levels were measured. The thiol-disulfide levels of the patients who were successful in H. pylori eradication treatment, with those who were not, were compared before and after the treatment. Results: The mean plasma disulphide level decreased significantly from 14.0 ± 6.6 to 10.9 ± 5.9 μmol/L in H. pylori-positive patients that responded to the H. pylori eradication treatment (P = 0.033). On the other hand, there was an insignificant increase in the mean serum thiol level (341.4 ± 30.5 vs. 342.6 ± 29.8 μmol/L; P = 0.273) and an insignificant decrease in the mean serum disulphide level (15.2 ± 2.5 vs. 14.8 ± 2.3 μmol/L; P = 0.163) in H. pylori-positive patients that did not respond to the H. pylori eradication treatment. Conclusion: The inflammation caused by H. pylori shifted the thiol-disulphide equilibrium in the cell redox system towards the direction of disulphide. The study findings suggest that the restoration of the said hemostatic balance with eradication therapy relieved the organism from oxidative stress.en_US
dc.identifier.citationEbik, B., Aslan, N., Ekin, N., Bacaksız, F., Arpa, M., Neşelioğlu, S. ve diğerleri. (2022). Oxidative stress and the importance of H. pylori eradication in patients with functional dyspepsia. Saudi Journal of Gastroenterology, 28(6), 434-440.en_US
dc.identifier.doi10.4103/sjg.sjg_114_22
dc.identifier.endpage440en_US
dc.identifier.issn1319-3767
dc.identifier.issue6en_US
dc.identifier.pmid35946262
dc.identifier.scopus2-s2.0-85143180560
dc.identifier.scopusqualityQ2
dc.identifier.startpage434en_US
dc.identifier.urihttps://journals.lww.com/sjga/fulltext/2022/28060/oxidative_stress_and_the_importance_of_h__pylori.6.aspx
dc.identifier.urihttps://hdl.handle.net/11468/13445
dc.identifier.volume28en_US
dc.identifier.wosWOS:000924078200006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUçmak, Feyzullah
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofSaudi Journal of Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEradicationen_US
dc.subjectHelicobacter pylorien_US
dc.subjectOxidative stressen_US
dc.subjectThiol-disulphide hemostasisen_US
dc.titleOxidative stress and the importance of H. pylori eradication in patients with functional dyspepsiaen_US
dc.titleOxidative stress and the importance of H. pylori eradication in patients with functional dyspepsia
dc.typeArticleen_US

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