Insulin Resistance in Type 2 Diabetes Mellitus May Be Related to Bone Mineral Density

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dc.contributor.authorArikan, Senay
dc.contributor.authorTuzcu, Alpaslan
dc.contributor.authorBahceci, Mithat
dc.contributor.authorOzmen, Sehmuz
dc.contributor.authorGokalp, Deniz
dc.date.accessioned2024-04-24T16:15:11Z
dc.date.available2024-04-24T16:15:11Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe mechanism of bone mineral density (BMD) changes in type 2 diabetes mellitus is not clear. We aimed to investigate the effect of insulin resistance in type 2 diabetics on BMD. Insulin resistance was determined using the homeostasis model assessment index (HOMA-IR). Nineteen type 2 diabetic patients with a HOMA-IR < 2.7 (mean age, 51.5 +/- 9.6 yr; body mass index [BMI] 27.3 +/- 5.1 kg/m(2); duration of diabetes, 10.5 +/- 7.3 yr) were included in Group A, and 30 BMI- and age-matched type 2 diabetic patients with a HOMA-IR >= 2.7 were included in Group B. The BMD was measured with dual-energy X-ray absorptiometry. Independent t-test was used for statistical analysis. The Group A values for mean fasting glucose and insulin levels were 160.1 +/- 77.0 mg/dL and 4.79 +/- 2.89 mu U/L, respectively, whereas the Group B values were 195.1 +/- 58.9 mg/dL (p > 0.05) and 19.30 +/- 16.89 mu U/L (p = 0.0001). Significantly higher total lumbar vertebra T-score (p = 0.02) and total lumbar vertebra BMD in Group A were determined than Group B (p = 0.033). The lumbar vertebra total Z-score was significantly lower in Group B (p = 0.042). Marked insulin resistance may have a negative effect on BMD in type 2 diabetics, while the presence of hyperinsulinemia may be associated with the low BMD.en_US
dc.identifier.doi10.1016/j.jocd.2011.11.005
dc.identifier.endpage190en_US
dc.identifier.issn1094-6950
dc.identifier.issue2en_US
dc.identifier.pmid22321655
dc.identifier.scopus2-s2.0-84860431976
dc.identifier.scopusqualityQ1
dc.identifier.startpage186en_US
dc.identifier.urihttps://doi.org/10.1016/j.jocd.2011.11.005
dc.identifier.urihttps://hdl.handle.net/11468/15696
dc.identifier.volume15en_US
dc.identifier.wosWOS:000304179000009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal of Clinical Densitometry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDxaen_US
dc.subjectInsulin Resistanceen_US
dc.subjectOsteoporosisen_US
dc.subjectType 2 Diabetes Mellitusen_US
dc.titleInsulin Resistance in Type 2 Diabetes Mellitus May Be Related to Bone Mineral Densityen_US
dc.titleInsulin Resistance in Type 2 Diabetes Mellitus May Be Related to Bone Mineral Density
dc.typeArticleen_US

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