Comparison of histopathologic findings of initial and recurrent lumbar disc herniation

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dc.authoridOzevren, Huseyin/0000-0002-5437-4003
dc.contributor.authorOzevren, Huseyin
dc.contributor.authorCetin, Abdurrahman
dc.contributor.authorBaloglu, Murat
dc.contributor.authorDeveci, Engin
dc.date.accessioned2025-02-22T14:08:58Z
dc.date.available2025-02-22T14:08:58Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectiveRecurrent lumbar disc hernia (RLDH) is a common and challenging complication after an initial discectomy. This study aimed to investigate the relationship between the histopathologic outcomes of the initial and recurrent disc tissues.MethodsThis study investigated 70 patients who underwent a microdiscectomy and subsequently developed same-level same-side lumbar disc herniation (LDH) recurrence. The clinic, western blot, and immunohistochemical evaluations of patients with initial LDH and RLDH were conducted and statistically analyzed.ResultsThe effect of inflammation and apoptosis in the degenerative changes of intervertebral disc hernia and increased histopathologic findings in RLDH was demonstrated. The degeneration of the hernia disc tissue is a major pathological process, which is characterized by cellular apoptosis, inflammation, and reduced synthesis of extracellular matrix. Currently, there is no clinical therapy targeting the reversal of disc degeneration.ConclusionsThis, therefore, stay away from factors that increase inflammation in the intervention of intervertebral disc hernia, applying to reduce inflammation the medicines, could allow reducing disc collagen degeneration, and more successful outcomes. These findings might shed some new lights on the mechanism of disc degeneration and provide new strategies for the treatments of initial and recurrent LDH.en_US
dc.identifier.doi10.1080/00207454.2024.2348123
dc.identifier.issn0020-7454
dc.identifier.issn1563-5279
dc.identifier.pmid38662772en_US
dc.identifier.scopus2-s2.0-85192347459en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/00207454.2024.2348123
dc.identifier.urihttps://hdl.handle.net/11468/29734
dc.identifier.wosWOS:001217319200001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal of Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectApoptosisen_US
dc.subjectdegenerationen_US
dc.subjectdisc herniationen_US
dc.subjectimmunohistochemicalen_US
dc.subjectmicrodiscectomyen_US
dc.titleComparison of histopathologic findings of initial and recurrent lumbar disc herniationen_US
dc.typeArticleen_US

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