Phytochemical Profiling by UHPLC-ESI-MS/MS, In Vitro Antioxidant, In Vivo Antidiabetic, and Pro-Sexual Effects of Salvia balansae Noë Ex Coss. Flower Extract in Diabetic Male Rats

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dc.authoridMohammed, Bouzouina/0000-0001-7134-3906
dc.authoridTARHAN, ABBAS/0000-0001-5196-3892
dc.authoridDAHOU, ABDELKADER ELAMINE/0000-0001-6640-3169
dc.authoridCakir, Oguz/0000-0002-8006-2054
dc.authoridYILMAZ, Mustafa Abdullah/0000-0002-4090-7227
dc.authoridFEKNOUS, Ines/0000-0003-2040-7417
dc.authoridSi Tayeb, Tayeb/0000-0001-8906-8842
dc.contributor.authorSouidi, Wadjila S.
dc.contributor.authorBelhocine, Mansouria
dc.contributor.authorBouzouina, Mohamed
dc.contributor.authorYilmaz, Mustafa A.
dc.contributor.authorFeknous, Ines
dc.contributor.authorCakir, Oguz
dc.contributor.authorTarhan, Abbas
dc.date.accessioned2025-02-22T14:09:11Z
dc.date.available2025-02-22T14:09:11Z
dc.date.issued2025
dc.departmentDicle Üniversitesien_US
dc.description.abstractOur study assessed the phytochemical composition and the effects of Salvia balansae flower aqueous extract (FAE) on sexual dysfunction in diabetic rats. Total phenolic and flavonoid content, quantification of phytochemicals by ultrahigh performance liquid chromatography (UHPLC)-electrospray ionization (ESI)-tandem mass spectrometry (MS/MS) method, and in vitro antioxidant capacity of FAE extract were elucidated. For the in vivo study, diabetes was induced by one intraperitoneal injection of streptozotocin (STZ) (40 mg/kg), and treated diabetic rats were given FAE at 200 mg/kg. Rats were subjected to a sexual incentive motivation test (SIM) and a mating behavior test, and then serum testosterone levels and sperm quality were analyzed. Our study indicates that FAE contained a large amount of phenolic compounds and flavonoids, and 13 constituents were quantified; cynaroside (3.8 mg analyte/g extract) was the main compound, followed by rosmarinic acid (3.145 mg analyte/g extract), thus confirming its high antioxidant capacity. FAE treatment significantly reduced blood glucose levels, improved sexual motivation and copulatory behavior, increased testosterone levels, and enhanced sperm quality in diabetic-treated rats compared to diabetic untreated rats. The present work demonstrates the therapeutic potential of S. balansae flowers in enhancing reproductive function in diabetic rats, potentially through its antioxidant, antihyperglycemic, and aphrodisiac properties.en_US
dc.identifier.doi10.1002/cbdv.202402552
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.pmid39763389en_US
dc.identifier.scopus2-s2.0-85215296836en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1002/cbdv.202402552
dc.identifier.urihttps://hdl.handle.net/11468/29823
dc.identifier.wosWOS:001397782700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistry & Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectantihyperglycemicen_US
dc.subjectantioxidantsen_US
dc.subjectphytochemistryen_US
dc.subjectSalvia balansaeen_US
dc.subjectultrahigh performance liquid chromatography (UHPLC)-electrospray ionization (ESI)-tandem mass spectrometry (MS/MS)en_US
dc.titlePhytochemical Profiling by UHPLC-ESI-MS/MS, In Vitro Antioxidant, In Vivo Antidiabetic, and Pro-Sexual Effects of Salvia balansae Noë Ex Coss. Flower Extract in Diabetic Male Ratsen_US
dc.typeArticleen_US

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