The Effect of Systemic Inflammation and Clinicopathologic Features on Survival in Malignant Pleural Mesothelioma: A Multicenter Analysis

dc.authoridSari, Murat/0000-0003-0596-1559
dc.authoridCIMIK, BERIVAN DENIZ/0009-0008-0410-003X
dc.authoridbayoglu, ibrahim vedat/0000-0002-0481-1084
dc.authoridALTINTAS, YUNUS EMRE/0000-0002-0634-7350
dc.authoridTUNC, Mustafa Alperen/0000-0002-1537-3032
dc.contributor.authorSever, Nadiye
dc.contributor.authorYildirim, Sedat
dc.contributor.authorGurbuz, Ali Fuat
dc.contributor.authorKilic, Delyadil Karakas
dc.contributor.authorZeynelgil, Esra
dc.contributor.authorAltintas, Yunus Emre
dc.contributor.authorCimik, Berivan Deniz
dc.date.accessioned2025-02-22T14:08:40Z
dc.date.available2025-02-22T14:08:40Z
dc.date.issued2025
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground and Objectives: Malignant pleural mesothelioma (MPM) is a rare and aggressive malignancy with a poor prognosis. Identifying reliable prognostic factors is crucial for risk stratification and optimizing treatment strategies. This study aimed to evaluate the impact of clinicopathologic factors and systemic inflammatory markers on survival outcomes in patients with MPM. Materials and Methods: This retrospective, multicenter study included 217 patients diagnosed with MPM between January 2009 and March 2024. Data on age, gender, histology, disease stage, treatment modalities, and inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein/albumin ratio (CAR) were collected. Survival outcomes were analyzed using Kaplan-Meier methods, and prognostic factors were evaluated using Cox regression analysis. Results: CAR was identified as an independent prognostic factor for both overall survival (OS) and progression-free survival (PFS). Patients with CAR < 0.98 had significantly longer OS (87.0 months vs. 14.0 months, p < 0.001) and PFS (17.61 months vs. 8.96 months, p = 0.010). While NLR was significant in univariate analysis (OS: 25.0 months for NLR < 2.58 vs. 21.0 months for NLR >= 2.58, p = 0.040), it did not retain significance in the multivariate model (p = 0.180). Epithelioid histology and early-stage disease were strongly associated with improved survival outcomes (OS: 32.0 vs. 11.0 months for epithelioid vs. non-epithelioid histology, p < 0.001; 32.0 vs. 12.0 months for early-stage vs. metastatic disease, p < 0.001). Conclusions: CAR is a strong independent prognostic factor in MPM, reflecting systemic inflammation and nutritional status. Epithelioid histology and early-stage disease are associated with significantly longer survival, underscoring the critical role of early detection in improving patient outcomes.en_US
dc.identifier.doi10.3390/medicina61010144
dc.identifier.issn1010-660X
dc.identifier.issn1648-9144
dc.identifier.issue1en_US
dc.identifier.pmid39859125en_US
dc.identifier.scopus2-s2.0-85215815432en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/medicina61010144
dc.identifier.urihttps://hdl.handle.net/11468/29552
dc.identifier.volume61en_US
dc.identifier.wosWOS:001405891300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofMedicina-Lithuaniaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectmalignant pleural mesotheliomaen_US
dc.subjectC-reactive protein/albumin ratio (CAR)en_US
dc.subjectneutrophil/lymphocyte ratio (NLR)en_US
dc.subjectepithelioid histologyen_US
dc.subjectsurvivalen_US
dc.titleThe Effect of Systemic Inflammation and Clinicopathologic Features on Survival in Malignant Pleural Mesothelioma: A Multicenter Analysisen_US
dc.typeArticleen_US

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