Effects of pharmacological treatments in alzheimer’s disease: Permutation entropy-based EEG complexity study

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dc.authorid0000-0002-7837-3996en_US
dc.authorid0000-0001-5535-4832en_US
dc.authorid0000-0002-7756-4387en_US
dc.authorid0000-0002-9368-8902en_US
dc.contributor.authorFide, Ezgi
dc.contributor.authorPolat, Hasan
dc.contributor.authorYener, Görsev
dc.contributor.authorÖzerdem, Mehmet Siraç
dc.date.accessioned2024-01-11T06:15:45Z
dc.date.available2024-01-11T06:15:45Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Mühendislik Fakültesi, Elektrik Elektronik Mühendisliği Bölümüen_US
dc.description.abstractAlzheimer’s disease (AD) is a neurodegenerative brain disease affecting cognitive and physical functioning. The currently available pharmacological treatments for AD mainly contain cholinesterase inhibitors (AChE-I) and N-methyl-d-aspartic acid (NMDA) receptor antagonists (i.e., memantine). Because brain signals have complex nonlinear dynamics, there has been an increase in interest in researching complexity changes in the time series of brain signals in individuals with AD. In this study, we explore the electroencephalographic (EEG) complexity for making better observation of pharmacological therapy-based treatment effects on AD patients using the permutation entropy (PE) method. We examined EEG sub-band (delta, theta, alpha, beta, and gamma) complexity in de-novo, monotherapy (AChE-I), dual therapy (AChE-I and memantine) receiving AD participants compared with healthy elderly controls. We showed that each frequency band depicts its own complexity profile, which is regionally altered between groups. These alterations were also found to be associated with global cognitive scores. Overall, our findings indicate that entropy measures could be useful to show medication effects in AD.en_US
dc.description.sponsorshipen_US
dc.identifier.citationFide, E., Polat, H., Yener, G. ve Özerdem, M. S. (2023). Effects of pharmacological treatments in alzheimer’s disease: Permutation entropy-based EEG complexity study. Brain Topography, 36(1), 106-118.en_US
dc.identifier.doi10.1007/s10548-022-00927-8
dc.identifier.endpage118en_US
dc.identifier.issn0896-0267
dc.identifier.issue1en_US
dc.identifier.pmid36399219
dc.identifier.scopus2-s2.0-85142132632
dc.identifier.scopusqualityQ2
dc.identifier.startpage106en_US
dc.identifier.urihttps://link.springer.com/article/10.1007/s10548-022-00927-8
dc.identifier.urihttps://hdl.handle.net/11468/13171
dc.identifier.volume36en_US
dc.identifier.wosWOS:000885213500002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzerdem, Mehmet Siraç
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofBrain Topography
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectDementia medicationsen_US
dc.subjectEEG complexityen_US
dc.subjectEEG frequenciesen_US
dc.subjectPermutation entropyen_US
dc.titleEffects of pharmacological treatments in alzheimer’s disease: Permutation entropy-based EEG complexity studyen_US
dc.titleEffects of pharmacological treatments in alzheimer’s disease: Permutation entropy-based EEG complexity study
dc.typeArticleen_US

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