The protective effect of Pomegranate extract against the experimental gastric ulcer induced by ethanol in rats

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dc.authorid0000-0002-0723-4059en_US
dc.authorid0000-0003-0396-7498en_US
dc.authorid0000-0002-9578-3786en_US
dc.authorid0000-0002-2758-913Xen_US
dc.authorid0000-0002-1546-9747en_US
dc.contributor.authorKarakoç, Zelal
dc.contributor.authorOruç, İdris
dc.contributor.authorToptancı, Bircan Çeken
dc.contributor.authorBaksi, Nazan
dc.contributor.authorKetani, Muzaffer Aydın
dc.date.accessioned2024-04-17T11:30:33Z
dc.date.available2024-04-17T11:30:33Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Temel Bilimler Bölümü, Laboratuvar Hayvanları Ana Bilim Dalıen_US
dc.description.abstractThe Pomegranate (Punica granatum) is a commonly found fruit in the Mediterranean and Iran, which has a variety of uses including medicinal purposes, cosmetics, and as a spice in culinary applications. Pharmacological functions of Pomegranate include antioxidation, anti–tumor, anti–hepatotoxicity, anti–lipoperoxidation and antibacterial properties. The aim of this study was to evaluate the therapeutic efficacy of Pomegranate extract by utilizing its antioxidant activity in an experimental rat model of gastritis induced by ethanol. In the study, 24 female Wistar albino rats (180–200 g) were used. Gastritis in rats was induced using Ethanol. In experimental groups, Tumor necrosis factor–alpha, Myloperoxidase, Superoxide Dismutase and Malondialdehyde were examined for biochemical analyzes. Streptavidin peroxidase immunohistochemistry method was applied to gastric tissues with gastritis. A statistically significant difference was observed between Superoxide Dismutase and Meloperoxidase levels. CD8 and CD68 immunoreactivity was higher in the Ethanol group compared to the other groups. A decrease was observed in CD8 and CD68 positive immunoreactivity in Ethanol+Pomegranate extract group compared to Ethanol group. The study found that the immunoreactivity of MHC–I and MHC–II was found in specific locations, namely intraepithelial lymphocytes located in the epithelium, some capillary vessel endothelium, and connective tissue. Changes in anti–oxidative stress markers such as Superoxide Dismutase and Myloperoxidase contributed to the mucosal protective effect of Pomegranate extract in Ethanol–induced gastritis.en_US
dc.description.abstractLa granada (Punica granatum) es una fruta que se encuentra comúnmente en el Mediterráneo e Irán, y que tiene una variedad de usos que incluyen fines medicinales, cosméticos y como especia en aplicaciones culinarias. Las funciones farmacológicas de la granada incluyen propiedades antioxidantes, antitumorales, anti hepatotoxicidad, anti lipoperoxidación y antibacterianas. El objetivo de este estudio fue evaluar la eficacia terapéutica del extracto de granada mediante la utilización de su actividad antioxidante en un modelo experimental de gastritis inducida por etanol en ratas. En el estudio se utilizaron 24 ratas albinas Wistar hembra (de 180 a 200 g). La gastritis en ratas se indujo utilizando etanol. En los grupos experimentales, se examinaron el factor de necrosis tumoral alfa, la mieloperoxidasa, la superóxido dismutasa y el malondialdehído para análisis bioquímicos. Se aplicó el método de inmunohistoquímica de estreptavidina peroxidasa a tejidos gástricos con gastritis. Se observó una diferencia estadísticamente significativa entre los niveles de superóxido dismutasa y mieloperoxidasa. La inmunorreactividad de CD8 y CD68 fue mayor en el grupo de etanol en comparación con los otros grupos. Se observó una disminución en la inmunorreactividad positiva para CD8 y CD68 en el grupo de etanol + extracto de granada en comparación con el grupo de etanol. El estudio encontró que la inmunorreactividad de MHC–I y MHC–II se encontró en ubicaciones específicas, a saber, linfocitos intraepiteliales ubicados en el epitelio, algunos endoteliales de vasos capilares y tejido conectivo. Los cambios en los marcadores de estrés antioxidante, como la superóxido dismutasa y la mieloperoxidasa, contribuyeron al efecto protector de la mucosa del extracto de granada en la gastritis inducida por etanol.en_US
dc.identifier.citationKarakoç, Z., Oruç, İ., Toptancı, B. Ç., Baksi, N. ve Ketani, N. B. (2024). The protective effect of Pomegranate extract against the experimental gastric ulcer induced by ethanol in rats. Revista Cientifica de la Facultad de Veterinaria, 34(1), 1-7.en_US
dc.identifier.doi10.52973/rcfcv-e34322en_US
dc.identifier.endpage7en_US
dc.identifier.issn0798-2259
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85185959264en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://produccioncientificaluz.org/index.php/cientifica/article/view/41583/48048
dc.identifier.urihttps://hdl.handle.net/11468/13909
dc.identifier.volume34en_US
dc.identifier.wosWOS:001179774400011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKarakoç, Zelal
dc.institutionauthorOruç, İdris
dc.institutionauthorToptancı, Bircan Çeken
dc.institutionauthorBaksi, Nazan
dc.institutionauthorKetani, Muzaffer Aydın
dc.language.isoenen_US
dc.publisherUniversidad del Zulia, Facultad de Ciencias Veterinariasen_US
dc.relation.ispartofRevista Cientifica de la Facultad de Veterinariaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGastritisen_US
dc.subjectImmunohistochemistryen_US
dc.subjectMHC class moleculesen_US
dc.subjectPomegranate extracten_US
dc.subjectRaten_US
dc.subjectInmunohistoquímicaen_US
dc.subjectMoléculas de clase MHCen_US
dc.subjectExtracto de granadaen_US
dc.subjectRataen_US
dc.titleThe protective effect of Pomegranate extract against the experimental gastric ulcer induced by ethanol in ratsen_US
dc.title.alternativeEl efecto protector del extracto de Granada contra la úlcera gástrica experimental inducida por etanol en ratasen_US
dc.typeArticleen_US

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