Evaluation of the effect of intraperitoneal etanercept administration on oxidative stress and inflammation indicators in the kidney and blood of experimental sepsis-induced rats

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dc.authorid0000-0001-5424-5714en_US
dc.authorid0000-0002-8101-2497en_US
dc.authorid0000-0001-5969-6127en_US
dc.authorid0000000213312906en_US
dc.authorid0000-0002-7768-2455en_US
dc.contributor.authorAydın, Emre E.
dc.contributor.authorYıldırım, Yaşar
dc.contributor.authorAydın, Fatma Yılmaz
dc.contributor.authorBahadır, Mehmet Veysi
dc.contributor.authorKaplan, İbrahim
dc.contributor.authorKadiroğlu, Berfin
dc.contributor.authorKetani, Muzaffer Aydın
dc.contributor.authorYılmaz, Zülfükar
dc.contributor.authorKadiroǧlu, Ali Kemal
dc.contributor.authorYılmaz, Mehmet Emin
dc.date.accessioned2021-08-27T07:07:01Z
dc.date.available2021-08-27T07:07:01Z
dc.date.issued2020en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractIntroduction: Sepsis is an important cause of mortality and morbidity, and inflammatory response and oxidative stress play major roles underlying its pathophysiology. Here, we evaluated the effect of intraperitoneal etanercept administration on oxidative stress and inflammation indicators in the kidney and blood of experimental sepsis-induced rats. Methods: Twenty-eight adult Sprague Dawley rats were classified into Control (Group 1), Sepsis (Group 2), Sepsis+Cefazolin (Group 3), and Sepsis+Cefazolin+Etanercept (Group 4) groups. Kidney tissue and serum samples were obtained for biochemical and histopathological investigations and examined for the C reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), triggering receptor expressed on myeloid cells (TREM), and malondialdehyde (MDA) levels. Results: The levels of TNF-α, TREM, and MDA in serum and kidney samples were significantly higher in rats from sepsis group than in rats from control group (p < 0.05). Group 3 showed a significant reduction in serum levels of TNF-α, CRP, and TREM as compared with Group 2 (p < 0.05). Serum TNF-α, CRP, TREM, and MDA levels and kidney TNF-α and TREM levels were significantly lower in Group 4 than in Group 2 (p < 0.05). Serum TNF-α and TREM levels in Group 4 were significantly lower than those in Group 3, and histopathological scores were significantly lower in Group 3 and Group 4 than in Group 2 (p < 0.05). Histopathological scores of Group 4 were significantly lower than those of Group 3 (p < 0.05). Conclusions: Etanercept, a TNF-α inhibitor, may ameliorate sepsis-induced oxidative stress, inflammation, and histopathological damage.en_US
dc.identifier.citationAydın, E. E., Yıldırım, Y., Aydın, F. Y., Bahadır, M. V., Kaplan, İ., Kadiroğlu ve diğerleri. (2020). Evaluation of the effect of intraperitoneal etanercept administration on oxidative stress and inflammation indicators in the kidney and blood of experimental sepsis-induced rats. Revista da Sociedade Brasileira de Medicina Tropical, 53,e20200016.en_US
dc.identifier.doi10.1590/0037-8682-0016-2020
dc.identifier.issn0037-8682
dc.identifier.pmid32348434
dc.identifier.scopus2-s2.0-85084170636
dc.identifier.scopusqualityQ2
dc.identifier.startpagee20200016en_US
dc.identifier.urihttps://www.scielo.br/j/rsbmt/a/YZ6FHy4pYBzQnnLYp54cYDK/?lang=en
dc.identifier.urihttps://hdl.handle.net/11468/7401
dc.identifier.volume53en_US
dc.identifier.wosWOS:000531557700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAydın, Emre E.
dc.institutionauthorYıldırım, Yaşar
dc.institutionauthorAydın, Fatma Yılmaz
dc.institutionauthorBahadır, Mehmet Veysi
dc.institutionauthorKaplan, İbrahim
dc.institutionauthorKadiroğlu, Berfin
dc.institutionauthorKetani, Muzaffer Aydın
dc.institutionauthorYılmaz, Zülfükar
dc.institutionauthorKadiroǧlu, Ali Kemal
dc.institutionauthorYılmaz, Mehmet Emin
dc.language.isoenen_US
dc.publisherSociedade Brasileira de Medicina Tropicalen_US
dc.relation.ispartofRevista da Sociedade Brasileira de Medicina Tropical
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEtanercepten_US
dc.subjectOxidative stressen_US
dc.subjectSepsisen_US
dc.subjectTNF-alphaen_US
dc.subjectTriggering receptor expressed on myeloid cellsen_US
dc.titleEvaluation of the effect of intraperitoneal etanercept administration on oxidative stress and inflammation indicators in the kidney and blood of experimental sepsis-induced ratsen_US
dc.titleEvaluation of the effect of intraperitoneal etanercept administration on oxidative stress and inflammation indicators in the kidney and blood of experimental sepsis-induced rats
dc.typeArticleen_US

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