Prevention of spinal epidural fibrosis by recombinant tissue plasminogen activator in rats

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dc.contributor.authorKemaloglu, S
dc.contributor.authorOzkan, U
dc.contributor.authorYilmaz, F
dc.contributor.authorNas, K
dc.contributor.authorGur, A
dc.contributor.authorAcemoglu, H
dc.contributor.authorKarasu, H
dc.date.accessioned2024-04-24T16:24:04Z
dc.date.available2024-04-24T16:24:04Z
dc.date.issued2003
dc.departmentDicle Üniversitesien_US
dc.description.abstractStudy design: A randomized-controlled experimental study was conducted to investigate the effectiveness of recombinant tissue plasminogen activator (rt-PA) on postlaminectomy epidural fibrosis in rats. Setting: Diyarbakir, Turkey. Methods: In a rat model, allowing objective histopathological quantification, the postoperative epidural scar formation was investigated and the potential of local rt-PA in preventing the production of epidural fibrosis was assessed. Rats were randomly allocated to local rt-PA (12 rats) or control (12 rats). Results: Findings suggest a beneficial effect of rt-PA in decreasing the epidural. fibrosis following laminectomy when compared with control groups for all investigated parameters such as intermuscular scar (P = 0.04), middle scar (P = 0.001), deep scar (P = 0.001) and dural adhesion (P = 0.01) except new bone formation. The presence of arachnoiditis was less in treatment group (P = 0.01). Conclusion: In rats, the topical thrombolysis with rt-PA is safe and efficacious in preventing postlaminectomy epidural. fibrosis. This Thrombolytic therapy with rt-PA after spine surgery may come to play an important role in the prevention of epidural fibrosis and arachnoiditis.en_US
dc.identifier.doi10.1038/sj.sc.3101466
dc.identifier.endpage431en_US
dc.identifier.issn1362-4393
dc.identifier.issue8en_US
dc.identifier.pmid12883539
dc.identifier.scopus2-s2.0-0041589076
dc.identifier.scopusqualityQ1
dc.identifier.startpage427en_US
dc.identifier.urihttps://doi.org/10.1038/sj.sc.3101466
dc.identifier.urihttps://hdl.handle.net/11468/16459
dc.identifier.volume41en_US
dc.identifier.wosWOS:000184796800002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofSpinal Cord
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSpinal Epidural Fibrosisen_US
dc.subjectLaminectomyen_US
dc.subjectRt-Paen_US
dc.titlePrevention of spinal epidural fibrosis by recombinant tissue plasminogen activator in ratsen_US
dc.titlePrevention of spinal epidural fibrosis by recombinant tissue plasminogen activator in rats
dc.typeArticleen_US

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