Effects of estrogen, estrogen/progesteron combination and genistein treatments on oxidant/antioxidant status in the brain of ovariectomized rats

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dc.contributor.authorEvsen, M. S.
dc.contributor.authorOzler, A.
dc.contributor.authorGocmez, C.
dc.contributor.authorVarol, S.
dc.contributor.authorTunc, S. Y.
dc.contributor.authorAkil, E.
dc.contributor.authorUzar, E.
dc.date.accessioned2024-04-24T17:33:40Z
dc.date.available2024-04-24T17:33:40Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractINTRODUCTION: The aim of this study was to investigate the antioxidative effects of estradiol (E), E plus progesteron (P) combination (E/P) and genistein (G) treatment in the brain of ovariectomized (OVX) rats. MATERIALS AND METHODS: Adult female Sprague-Dawley rats were divided into five groups, with each group including ten rats. Rats were anesthetized and bilateral ovariectomy was performed under general anaesthesia in all groups except for the sham operation group. Groups included: Sham-operated, control (OVX), estrogen treated group (OVX+ E), E/P combination group (OVX+ E/P) and G treated group (OVX+ G). Treatments were applied for 8 weeks. The total anti-oxidant status (TAS), total oxidant status (TOS), nitric oxide level (NO), glutathione peroxidase activity (GSH-Px) and oxidative stress index (OSI) were analysed in the brain tissue of rats from each treatment category. RESULTS: Ovariectomy lead to an increase in brain TOS and OSI levels compared to the sham group (p < 0.05). Also, ovariectomy resulted in a decrease in brain TAS levels compared to the sham group that approached statistical significance (p = 0.078). Significant decreases in TOS, OSI, GSH-Px and a significant increases in TAS and NO levels were observed in the E-treatment group compared to the control group (p < 0.001). The E/P combination group exhibited a significantly decreased TOS and OSI and significantly increased TAS and NO levels relative to the control group (p < 0.05). Genistein treatment resulted in a significant decrease in TOS and OSI compared to the control group (p < 0.05). CONCLUSIONS: Oxidative stress markers increase in the brain tissue of OVX rats. Conversely, estradiol, E/P and G supplementation decreases oxidative stress markers and increases antioxidant activity. Using G may prevent neural pathologies result in menopause-related oxidative stress.en_US
dc.identifier.endpage1873en_US
dc.identifier.issn1128-3602
dc.identifier.issue14en_US
dc.identifier.pmid23877849
dc.identifier.scopus2-s2.0-84884170011
dc.identifier.scopusqualityQ2
dc.identifier.startpage1869en_US
dc.identifier.urihttps://hdl.handle.net/11468/20796
dc.identifier.volume17en_US
dc.identifier.wosWOS:000325203900005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRaten_US
dc.subjectBrainen_US
dc.subjectOxidative Stressen_US
dc.subjectMenopauseen_US
dc.subjectGenisteinen_US
dc.titleEffects of estrogen, estrogen/progesteron combination and genistein treatments on oxidant/antioxidant status in the brain of ovariectomized ratsen_US
dc.titleEffects of estrogen, estrogen/progesteron combination and genistein treatments on oxidant/antioxidant status in the brain of ovariectomized rats
dc.typeArticleen_US

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