The microbiological diagnosis of tuberculous meningitis: results of Haydarpasa-1 study

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dc.contributor.authorErdem, H.
dc.contributor.authorOzturk-Engin, D.
dc.contributor.authorElaldi, N.
dc.contributor.authorGulsun, S.
dc.contributor.authorSengoz, G.
dc.contributor.authorCrisan, A.
dc.contributor.authorJohansen, I. S.
dc.date.accessioned2024-04-24T17:11:23Z
dc.date.available2024-04-24T17:11:23Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractWe aimed to provide data on the diagnosis of tuberculous meningitis (TBM) in this largest case series ever reported. The Haydarpasa-1 study involved patients with microbiologically confirmed TBM in Albania, Croatia, Denmark, Egypt, France, Hungary, Iraq, Italy, Macedonia, Romania, Serbia, Slovenia, Syria and Turkey between 2000 and 2012. A positive culture, PCR or Ehrlich-Ziehl-Neelsen staining (EZNs) from the cerebrospinal fluid (CSF) was mandatory for inclusion of meningitis patients. A total of 506 TBM patients were included. The sensitivities of the tests were as follows: interferon- release assay (Quantiferon TB gold in tube) 90.2%, automated culture systems (ACS) 81.8%, Lowenstein Jensen medium (L-J) 72.7%, adenosine deaminase (ADA) 29.9% and EZNs 27.3%. CSF-ACS was superior to CSF L-J culture and CSF-PCR (p<0.05 for both). Accordingly, CSF L-J culture was superior to CSF-PCR (p<0.05). Combination of L-J and ACS was superior to using these tests alone (p<0.05). There were poor and inverse agreements between EZNs and L-J culture (=-0.189); ACS and L-J culture (=-0.172) (p<0.05 for both). Fair and inverse agreement was detected for CSF-ADA and CSF-PCR (=-0.299, p<0.05). Diagnostic accuracy of TBM was increased when both ACS and L-J cultures were used together. Non-culture tests contributed to TBM diagnosis to a degree. However, due to the delays in the diagnosis with any of the cultures, combined use of non-culture tests appears to contribute early diagnosis. Hence, the diagnostic approach to TBM should be individualized according to the technical capacities of medical institutions particularly in those with poor resources.en_US
dc.identifier.doi10.1111/1469-0691.12478
dc.identifier.endpageO608en_US
dc.identifier.issn1198-743X
dc.identifier.issn1469-0691
dc.identifier.issue10en_US
dc.identifier.pmid24849547
dc.identifier.scopus2-s2.0-84913605718
dc.identifier.scopusqualityQ1
dc.identifier.startpageO600en_US
dc.identifier.urihttps://doi.org/10.1111/1469-0691.12478
dc.identifier.urihttps://hdl.handle.net/11468/17468
dc.identifier.volume20en_US
dc.identifier.wosWOS:000345825900004
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofClinical Microbiology and Infection
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCultureen_US
dc.subjectDiagnosisen_US
dc.subjectMeningitisen_US
dc.subjectPcren_US
dc.subjectTuberculosisen_US
dc.titleThe microbiological diagnosis of tuberculous meningitis: results of Haydarpasa-1 studyen_US
dc.titleThe microbiological diagnosis of tuberculous meningitis: results of Haydarpasa-1 study
dc.typeArticleen_US

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