Neuroprotective effects of ganoderma lucidum on spinal cord injury

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dc.authorid0000-0002-5437-4003en_US
dc.authorid0000-0002-2325-7277en_US
dc.authorid0000-0002-2353-1184en_US
dc.authorid0000-0002-0547-4139en_US
dc.contributor.authorEkinci, Aysun
dc.contributor.authorÖzevren, Hüseyin
dc.contributor.authorBilgiç, Bülent Emre
dc.contributor.authorEkinci, Cenap
dc.contributor.authorDeveci, Şenay
dc.contributor.authorDeveci, Engin
dc.date.accessioned2022-12-09T12:12:11Z
dc.date.available2022-12-09T12:12:11Z
dc.date.issued2018en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.description.abstractTraumatic injury to the spinal cord results in the delayed dysfunction and neuronal death. Impaired mitochondrial function, generation of reactive oxygen species (ROS), and lipid peroxidation occur soon after traumatic spinal cord injury (SCI), while the activation of compensatory molecules that neutralize ROS occurs at later time points. The aim of the current study was to investigate the putative neuroprotective effect of Ganoderma lucidum in a rat model of SCI. In order to induce SCI, a standard weight-drop method that induced a moderately severe injury (100 g/cm force) at T10, was used. Injured animals were given either 20 mL/kg Ganoderma lucidum or saline 30 min post injury per day by gastric gavage. At seven days postinjury, rats were decapitated. Spinal cord samples were taken for histological examination or determination of malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity. SCI caused a significant decrease in spinal cord GSH content, which was accompanied with significant increases in MDA levels, MPO activity. On the other hand, Ganoderma lucidum treatment reversed all these biochemical parameters as well as SCI-induced histopathological alterations. Furthermore, impairment of the neurological functions due to SCI was improved by meloxicam treatment. The present study suggests that Ganoderma Lucidum, reduces SCI-induced oxidative stress and exerts neuroprotection by inhibiting lipid peroxidation, GSH depletion.en_US
dc.identifier.citationEkinci, A., Özevren, H., Bilgiç, B. E., Ekinci, C., Deveci, Ş. ve Deveci, E. (2018). Neuroprotective effects of ganoderma lucidum on spinal cord injury. International Journal of Morphology, 36(1), 175-179.en_US
dc.identifier.doi10.4067/S0717-95022018000100175en_US
dc.identifier.endpage179en_US
dc.identifier.issn0717-9367
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85044595624en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage175en_US
dc.identifier.urihttps://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100175&lng=en&nrm=iso&tlng=en
dc.identifier.urihttps://hdl.handle.net/11468/11003
dc.identifier.volume36en_US
dc.identifier.wosWOS:000438813400030
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorEkinci, Aysun
dc.institutionauthorÖzevren, Hüseyin
dc.institutionauthorEkinci, Cenap
dc.institutionauthorDeveci, Şenay
dc.institutionauthorDeveci, Engin
dc.language.isoenen_US
dc.publisherUniversidad de la Fronteraen_US
dc.relation.ispartofInternational Journal of Morphologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSpinal cord injuryen_US
dc.subjectGanoderma lucidumen_US
dc.subjectVEGFen_US
dc.subjectPCNAen_US
dc.titleNeuroprotective effects of ganoderma lucidum on spinal cord injuryen_US
dc.title.alternativeEfectos neuroprotectores de ganoderma lucidum en la lesión de la médula espinal len_US
dc.typeArticleen_US

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