Pentoxifylline and electromagnetic field improved bone fracture healing in rats

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dc.contributor.authorAtalay, Yusuf
dc.contributor.authorGunes, Nedim
dc.contributor.authorGuner, Mehmet Dervis
dc.contributor.authorAkpolat, Veysi
dc.contributor.authorCelik, Mustafa Salih
dc.contributor.authorGuner, Rezzan
dc.date.accessioned2024-04-24T17:18:27Z
dc.date.available2024-04-24T17:18:27Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: The aim of this study was to evaluate the effects of a phosphodiesterase inhibitor pentoxifylline (PTX), electromagnetic fields (EMFs), and a mixture of both materials on bone fracture healing in a rat model. Materials and methods: Eighty male Wistar rats were randomly divided into four groups: Group A, femur fracture model with no treatment; Group B, femur fracture model treated with PTX 50 mg/kg/day intraperitoneal injection; Group C, femur fracture model treated with EMF 1.5 +/- 0.2 Mt/50 Hz/6 hours/day; and Group D, femur fracture model treated with PTX 50 mg/kg/day intraperitoneal injection and EMF 1.5 +/- 0.2 Mt/50 Hz/6 hours/day. Results: Bone fracture healing was significantly better in Group B and Group C compared to Group A (P<0.05), but Group D did not show better bone fracture healing than Group A (P>0.05). Conclusion: It can be concluded that both a specific EMF and PTX had a positive effect on bone fracture healing but when used in combination, may not be beneficial.en_US
dc.description.sponsorshipDicle Universityen_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects of Dicle University.en_US
dc.identifier.doi10.2147/DDDT.S89669
dc.identifier.endpage5201en_US
dc.identifier.issn1177-8881
dc.identifier.pmid26388687
dc.identifier.scopus2-s2.0-84941254117
dc.identifier.scopusqualityQ1
dc.identifier.startpage5195en_US
dc.identifier.urihttps://doi.org/10.2147/DDDT.S89669
dc.identifier.urihttps://hdl.handle.net/11468/18788
dc.identifier.volume9en_US
dc.identifier.wosWOS:000361015500002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofDrug Design Development and Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBonesen_US
dc.subjectElectromagnetic Fieldsen_US
dc.subjectFracture Healingen_US
dc.subjectPhosphodiesterase Inhibitoren_US
dc.subjectPentoxifyllineen_US
dc.subjectRatsen_US
dc.titlePentoxifylline and electromagnetic field improved bone fracture healing in ratsen_US
dc.titlePentoxifylline and electromagnetic field improved bone fracture healing in rats
dc.typeArticleen_US

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