Protective activity of Hertia cheirifolia extracts against DNA damage, lipid peroxidation and protein oxidation

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dc.contributor.authorKada, Seoussen
dc.contributor.authorBouriche, Hamama
dc.contributor.authorSenator, Abderrahmane
dc.contributor.authorDemirtas, Ibrahim
dc.contributor.authorOzen, Tevfik
dc.contributor.authorToptanci, Bircan Ceken
dc.contributor.authorKizil, Goksel
dc.date.accessioned2024-04-24T17:07:46Z
dc.date.available2024-04-24T17:07:46Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractContext: Hertia cheirifolia L. (Asteraceae), a perennial shrub widely distributed in Northern Africa, is traditionally used to treat inflammatory disorders. Objective: The protective effect of methanol (Met E) and aqueous (Aq E) extracts of Hertia cheirifolia against DNA, lipid and protein oxidation was investigated. Materials and methods: Different concentrations (50-1000 mu g/mL) of Hertia cheirifolia aerial part extracts were examined against DNA, lipid and protein oxidation induced by H2O2 +UV, FeSO4, and Fe3+/H2O2-ascorbic acid, respectively. The DPPH center dot, metal ion chelating, reducing power and beta-carotene bleaching tests were conducted. Results: Both extracts were rich in polyphenols, flavonoids and tannins, and were able to scavenge DPPH center dot with IC50 values of 138 and 197 mu g/mL, respectively. At 300 mu g/mL, Aq E exerted stronger chelating effect (99%) than Met E (69%). However, Met E reducing power (IC50 = 61 mu g/mL) was more than that of Aq E (IC50 = 193 mu g/mL). Both extracts protected from beta-carotene bleaching by 74% and 94%, respectively, and inhibited linoleic acid peroxidation. The inhibitory activity of Aq E extract (64%) was twice more than that of Met E (32%). Interestingly, both extracts protected DNA against the cleavage by about 96-98%. At 1 mg/mL, Met E and Aq E restored protein band intensity by 94-99%. Conclusions: Hertia cheirifolia exhibits potent antioxidant activity and protects biomolecules against oxidative damage; hence, it may serve as potential source of natural antioxidant for pharmaceutical applications and food preservation. This is the first report on the protective activity of this plant against biomolecule oxidation.en_US
dc.identifier.doi10.1080/13880209.2016.1261907
dc.identifier.endpage337en_US
dc.identifier.issn1388-0209
dc.identifier.issn1744-5116
dc.identifier.issue1en_US
dc.identifier.pmid27927074
dc.identifier.scopus2-s2.0-85015348415
dc.identifier.scopusqualityQ1
dc.identifier.startpage330en_US
dc.identifier.urihttps://doi.org/10.1080/13880209.2016.1261907
dc.identifier.urihttps://hdl.handle.net/11468/16976
dc.identifier.volume55en_US
dc.identifier.wosWOS:000390846600034
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPharmaceutical Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidant Activityen_US
dc.subjectBiomolecule Lesionsen_US
dc.subjectMedicinal Planten_US
dc.subjectOxidative Stressen_US
dc.subjectPolyphenolsen_US
dc.titleProtective activity of Hertia cheirifolia extracts against DNA damage, lipid peroxidation and protein oxidationen_US
dc.titleProtective activity of Hertia cheirifolia extracts against DNA damage, lipid peroxidation and protein oxidation
dc.typeArticleen_US

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