Towards a better understanding of commonly used medicinal plants from Turkiye: Detailed phytochemical screening and biological activity studies of two Teucrium L. species with in vitro and in silico approach

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dc.authorid0000-0002-6913-1952en_US
dc.authorid0000-0002-9528-6122en_US
dc.authorid0000-0002-1569-2535en_US
dc.authorid0000-0001-5784-7091en_US
dc.contributor.authorErsoy, Ezgi
dc.contributor.authorSüvari, Goncagül
dc.contributor.authorErcan, Selami
dc.contributor.authorÖzkan, Esra Eroğlu
dc.contributor.authorKarahan, Selim
dc.contributor.authorTuncay, Evin Aygün
dc.contributor.authorBoğa, Mehmet
dc.date.accessioned2023-10-06T12:23:49Z
dc.date.available2023-10-06T12:23:49Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractEthnopharmacological relevance: Since ancient times, Teucrium L. species have been among the most commonly used traditional medicinal plants mainly in the Mediterranean region. From tackling gastrointestinal problems to maintaining the healthy functioning of endocrine glands, and from treating malaria to severe dermatological disorders, Teucrium species are known to have extensive therapeutic applications. Teucrium polium L. and Teucrium parviflorum Schreb. are the two members of the genus that have been used in Turkish folk medicine for various medicinal purposes. Aim of the study: To determine the phytochemical compositions of the essential oils and ethanol extracts of Teucrium polium and Teucrium parviflorum collected from different locations in Turkiye along with the investigation of in vitro antioxidant, anticancer, antimicrobial activities, and both in vitro and in silico enzyme inhibitory activities of the extracts. Materials and methods: Ethanol extracts of Teucrium polium aerial parts and roots, and aerial parts of Teucrium parviflorum were prepared. Volatile profiling of the essential oils by GC-MS, phytochemical profiling of the ethanol extracts by LC-HRMS, antioxidant activity by DPPH radical scavenging, ABTS cation radical scavenging, CUPRAC, and metal chelating activity assays, anticholinesterase, antityrosinase, antiurease, activities by different enzyme inhibitory activity assays, anticancer activity by SRB cell viability assay, and antimicrobial activity against a standard panel of bacteria and fungi by the microbroth dilution technique. Molecular docking studies were performed by Autodock Vina (Ver. 1.1.2). Results: The studied extracts were found to be quite rich in various biologically important volatile and phenolic compounds. (−)-Epigallocatechin gallate, which is a molecule renowned for having great therapeutic potential, was the major compound of all extracts. Teucrium polium aerial parts extract was revealed as a great source for naringenin with 16327 ± 685.23 μg/g extract. All extracts exerted significant antioxidant activity by different methods. All extracts demonstrated antibutrylcholinesterase, antityrosinase, and antiurease activities by in vitro and in silico assays. Teucrium polium roots extract stood out with remarkable tyrosinase and urease inhibitory and cytotoxic activities. Conclusion: The obtained results from this multi-disciplinary study proves that the traditional use of these two Teucrium species is justified, and the mechanisms behind are enlightened.en_US
dc.description.sponsorshipDUBAP (Dicle University Scientific Research Projects Coordinator) BAP/19.003en_US
dc.identifier.citationErsoy, E., Süvari, G., Ercan, S., Özkan, E. E., Karahan, S., Tuncay, E. A. ve diğerleri. (2023). Towards a better understanding of commonly used medicinal plants from Turkiye: Detailed phytochemical screening and biological activity studies of two Teucrium L. species with in vitro and in silico approach. Journal of Ethnopharmacology, (312), 116482en_US
dc.identifier.doi10.1016/j.jep.2023.116482
dc.identifier.endpage20en_US
dc.identifier.issn0378-8741
dc.identifier.issue312en_US
dc.identifier.pmid37059244
dc.identifier.scopus2-s2.0-85152523520
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0378874123003501?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/12770
dc.identifier.wosWOS:000984545000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSüvari, Goncagül
dc.institutionauthorKarahan, Selim
dc.institutionauthorTuncay, Evin Aygün
dc.institutionauthorBoğa, Mehmet
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltd.en_US
dc.relation.ispartofJournal of Ethnopharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiological activityen_US
dc.subjectGC-MSen_US
dc.subjectLC-HRMSen_US
dc.subjectMolecular dockingen_US
dc.subjectTeucriumen_US
dc.titleTowards a better understanding of commonly used medicinal plants from Turkiye: Detailed phytochemical screening and biological activity studies of two Teucrium L. species with in vitro and in silico approachen_US
dc.titleTowards a better understanding of commonly used medicinal plants from Turkiye: Detailed phytochemical screening and biological activity studies of two Teucrium L. species with in vitro and in silico approach
dc.typeArticleen_US

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