Synthesis, characterization, DNA interaction and docking studies of novel Schiff base ligand derived from 2,6-diaminopyridine and its complexes

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dc.contributor.authorKurt, Baris
dc.contributor.authorTemel, Hamdi
dc.contributor.authorAtlan, Metin
dc.contributor.authorKaya, Savas
dc.date.accessioned2024-04-24T16:15:37Z
dc.date.available2024-04-24T16:15:37Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn this study [1-(4-{[(3-hydroxynaphthalen-2-yl)methylidene]amino}phenyl)ethan-1- one (B-1 ligand) were synthesized from the reaction of 2-hydroxy-1-naphthaldehyde with 4-amino-acetophenone. Following that 1-(N-{4-[(1)-1-({6-[(Z)-[1-(4-{[(3- hydroxynaphthalen-2-yl) methylidene]amino}phenyl) ethylidene]amino]pyridine2- yl}imino)ethyl]phenyl}carboximidoyl)naphthalen-2-ol (L-1 ligand) were synthesized from the reaction of 2,6-diamino pyridine with B-1 ligand. Using this Schiff base ligand Cu(II), Fe(II) and Pd(II) complexes were prepared. The structure of the ligand and its complexes were determined by H-1 NMR, FTIR, UV-Vis, elemental analysis, thermal analyses and magnetic susceptibility spectral data. Further, DNA binding properties of the ligand and its metal complexes were investigated and docking studies were carried out. As a result ligands and copper complex showed DNA binding activity and an increase with H2O2. According to these results it can be suggested that these compounds are very suitable drug candidates. (C) 2020 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.molstruc.2020.127928
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85079855001
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2020.127928
dc.identifier.urihttps://hdl.handle.net/11468/15872
dc.identifier.volume1209en_US
dc.identifier.wosWOS:000522727600051
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSchiff Baseen_US
dc.subjectMetal Complexesen_US
dc.subjectDna Binding Studyen_US
dc.subjectMolecular Dockingen_US
dc.titleSynthesis, characterization, DNA interaction and docking studies of novel Schiff base ligand derived from 2,6-diaminopyridine and its complexesen_US
dc.titleSynthesis, characterization, DNA interaction and docking studies of novel Schiff base ligand derived from 2,6-diaminopyridine and its complexes
dc.typeArticleen_US

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