Synthesis, characterization, DNA interaction and docking studies of novel Schiff base ligand derived from 2,6-diaminopyridine and its complexes
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Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study [1-(4-{[(3-hydroxynaphthalen-2-yl)methylidene]amino}phenyl)ethan-1- one (B-1 ligand) were synthesized from the reaction of 2-hydroxy-1-naphthaldehyde with 4-amino-acetophenone. Following that 1-(N-{4-[(1)-1-({6-[(Z)-[1-(4-{[(3- hydroxynaphthalen-2-yl) methylidene]amino}phenyl) ethylidene]amino]pyridine2- yl}imino)ethyl]phenyl}carboximidoyl)naphthalen-2-ol (L-1 ligand) were synthesized from the reaction of 2,6-diamino pyridine with B-1 ligand. Using this Schiff base ligand Cu(II), Fe(II) and Pd(II) complexes were prepared. The structure of the ligand and its complexes were determined by H-1 NMR, FTIR, UV-Vis, elemental analysis, thermal analyses and magnetic susceptibility spectral data. Further, DNA binding properties of the ligand and its metal complexes were investigated and docking studies were carried out. As a result ligands and copper complex showed DNA binding activity and an increase with H2O2. According to these results it can be suggested that these compounds are very suitable drug candidates. (C) 2020 Elsevier B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
Schiff Base, Metal Complexes, Dna Binding Study, Molecular Docking
Kaynak
Journal of Molecular Structure
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
1209
