Osteopontin expression in the intestine of chukar partridge (Alectoris chukar, Gray, 1830)

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dc.contributor.authorAkbalik, Mehmet E.
dc.contributor.authorSagsoz, Hakan
dc.contributor.authorErdogan, Serkan
dc.date.accessioned2024-04-24T17:14:30Z
dc.date.available2024-04-24T17:14:30Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe intestinal mucosa is under continuous attack of microorganisms and is defended by the joint action of epithelial cells and specialized immune cells. Osteopontin (OPN), a member of the Small Integrin-Binding Ligand, N-linked Glycoprotein (SIBLING) family, is an adhesive phosphorylated glyco-protein that is synthesized by a variety of nonimmune and immune cells that is involved in interactions with cells mediating signaling. OPN is especially required for the maintenance of the epithelial barrier. To gain a better understanding of the biology of OPN, in the avian intestinal tract, we examined subcellular localization of OPN in the small and large intestine using immunohistochemistry. Immunostaining for OPN was prominently and significantly detected in the epithelial cells of the small and large intestine. However, intestinal stromal cells of the small intestine and the smooth muscle cells in the wall of the large intestine did not exhibit OPN immunoreactivity. Our results show that the differences between the localizations of OPN in the chukar partridge's small and large intestine may be associated with functional differences of intestine parts. Therefore, the expression of OPN in the chukar partridge intestine may play a crucial role in barrier function, host defence, and/or secretion.en_US
dc.identifier.doi10.1163/15707563-00002477
dc.identifier.endpage298en_US
dc.identifier.issn1570-7555
dc.identifier.issn1570-7563
dc.identifier.issue3-4en_US
dc.identifier.scopus2-s2.0-84957102968
dc.identifier.scopusqualityQ2
dc.identifier.startpage287en_US
dc.identifier.urihttps://doi.org/10.1163/15707563-00002477
dc.identifier.urihttps://hdl.handle.net/11468/18006
dc.identifier.volume65en_US
dc.identifier.wosWOS:000367519100008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherBrill Academic Publishersen_US
dc.relation.ispartofAnimal Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBarrier Functionen_US
dc.subjectImmunohistochemistryen_US
dc.subjectIntestineen_US
dc.subjectOsteopontinen_US
dc.subjectPartridgeen_US
dc.titleOsteopontin expression in the intestine of chukar partridge (Alectoris chukar, Gray, 1830)en_US
dc.titleOsteopontin expression in the intestine of chukar partridge (Alectoris chukar, Gray, 1830)
dc.typeArticleen_US

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