Osteopontin expression in the intestine of chukar partridge (Alectoris chukar, Gray, 1830)
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Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Brill Academic Publishers
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The intestinal mucosa is under continuous attack of microorganisms and is defended by the joint action of epithelial cells and specialized immune cells. Osteopontin (OPN), a member of the Small Integrin-Binding Ligand, N-linked Glycoprotein (SIBLING) family, is an adhesive phosphorylated glyco-protein that is synthesized by a variety of nonimmune and immune cells that is involved in interactions with cells mediating signaling. OPN is especially required for the maintenance of the epithelial barrier. To gain a better understanding of the biology of OPN, in the avian intestinal tract, we examined subcellular localization of OPN in the small and large intestine using immunohistochemistry. Immunostaining for OPN was prominently and significantly detected in the epithelial cells of the small and large intestine. However, intestinal stromal cells of the small intestine and the smooth muscle cells in the wall of the large intestine did not exhibit OPN immunoreactivity. Our results show that the differences between the localizations of OPN in the chukar partridge's small and large intestine may be associated with functional differences of intestine parts. Therefore, the expression of OPN in the chukar partridge intestine may play a crucial role in barrier function, host defence, and/or secretion.
Açıklama
Anahtar Kelimeler
Barrier Function, Immunohistochemistry, Intestine, Osteopontin, Partridge
Kaynak
Animal Biology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
65
Sayı
3-4
