Effect of hypoglycemic drugs on aspirin resistance in patients with diabetes mellitus

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dc.contributor.authorAriturk, Z.
dc.contributor.authorIslamoglu, Y.
dc.contributor.authorGunduz, E.
dc.contributor.authorYavuz, C.
dc.contributor.authorCil, H.
dc.contributor.authorTekbas, E.
dc.contributor.authorSoydinc, S.
dc.date.accessioned2024-04-24T17:33:34Z
dc.date.available2024-04-24T17:33:34Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Aspirin reduces the odds of an arterial thrombotic event in high-risk patients. However, 10%-20% of patients with an arterial thrombotic event who are treated with aspirin have a recurrent arterial thrombotic event during long-term followup. Aspirin resistance has been described in some patient populations such as those with an acute coronary syndrome, ischemic stroke, percutaneous coronary intervention with drug-eluting stent, stent re-stenosis, and diabetes mellitus (DM). The aim of this study was to assess aspirin resistance and to compare it to the use of oral anti-diabetic drugs and insulin in patients with diabetes. Methods and Results: Platelet aggregation was measured after aspirin treatment in 101 diabetic patients undergoing percutaneous coronary intervention. Two patient populations were included in the investigation: use of insulin (group 1) and use of oral anti-diabetic agents (OAD) (group 2) in diabetic patients. Platelet aggregation was determined using a multichannel Multiplate analyzer. Among group 1 patients, 4.7% were aspirin non-responders and among group 2 patients, 8.6% were aspirin non-responders. Statistical differences were not found between the groups (p = 0.359). Conclusions: This study demonstrated that there was no significant difference in aspirin resistance between type 2 diabetes mellitus patients on insulin treatment and type 2 diabetes mellitus patients on OAD treatment.en_US
dc.identifier.endpage621en_US
dc.identifier.issn1128-3602
dc.identifier.issue5en_US
dc.identifier.pmid22774402
dc.identifier.scopus2-s2.0-84864086231
dc.identifier.scopusqualityQ2
dc.identifier.startpage617en_US
dc.identifier.urihttps://hdl.handle.net/11468/20752
dc.identifier.volume16en_US
dc.identifier.wosWOS:000305663400008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAspirinen_US
dc.subjectPlateletsen_US
dc.subjectDiabetes Mellitusen_US
dc.titleEffect of hypoglycemic drugs on aspirin resistance in patients with diabetes mellitusen_US
dc.titleEffect of hypoglycemic drugs on aspirin resistance in patients with diabetes mellitus
dc.typeArticleen_US

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