Synthesis and characterisation of novel tricyclic and tetracyclic furoindoles: Biological evaluation as SAHA enhancer against neuroblastoma and breast cancer cells

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dc.authorid0000-0002-3909-0694en_US
dc.contributor.authorBingül, Murat
dc.contributor.authorArndt, Greg M.
dc.contributor.authorMarshall, Glenn M.
dc.contributor.authorSt. Black, David C.C.
dc.contributor.authorCheung, Belamy
dc.contributor.authorKumar, Naresh Sampath
dc.date.accessioned2022-03-11T08:05:40Z
dc.date.available2022-03-11T08:05:40Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.descriptionPMID: 34641289
dc.descriptionWOS:000708237400001
dc.description.abstractThe dihydropyranoindole structures were previously identified as promising scaffolds for improving the anti-cancer activity of histone deacetylase inhibitors. This work describes the synthesis of related furoindoles and their ability to synergize with suberoylanilide hydroxamic acid (SAHA) against neuroblastoma and breast cancer cells. The nucleophilic substitution of hydroxyin-dole methyl esters with α-haloketones yielded the corresponding arylether ketones, which were subsequently cyclized to tricyclic and tetracyclic furoindoles. The furoindoles showed promising individual cytotoxic efficiency against breast cancer cells, as well as decent SAHA enhancement against cancer cells in select cases. Interestingly, the best IC50 value was obtained with the non-cyclized intermediate.en_US
dc.identifier.citationBingül, M., Arndt, G. M., Marshall, G. M., St. Black, D. C.C., Cheung, B. ve Kumar, N. S. (2021). Synthesis and characterisation of novel tricyclic and tetracyclic furoindoles: Biological evaluation as SAHA enhancer against neuroblastoma and breast cancer cells. Molecules, 26(19), 5745.en_US
dc.identifier.doi10.3390/molecules26195745
dc.identifier.issn1420-3049
dc.identifier.issue19en_US
dc.identifier.pmid34641289
dc.identifier.scopus2-s2.0-85115725937
dc.identifier.scopusqualityQ1
dc.identifier.startpage5745en_US
dc.identifier.urihttps://www.mdpi.com/1420-3049/26/19/5745
dc.identifier.urihttps://hdl.handle.net/11468/9387
dc.identifier.volume26en_US
dc.identifier.wosWOS:000708237400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBingül, Murat
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofMolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBreast canceren_US
dc.subjectFuroindoleen_US
dc.subjectHDAC inhibitorsen_US
dc.subjectNeuroblastomaen_US
dc.subjectSAHA enhancementen_US
dc.titleSynthesis and characterisation of novel tricyclic and tetracyclic furoindoles: Biological evaluation as SAHA enhancer against neuroblastoma and breast cancer cellsen_US
dc.titleSynthesis and characterisation of novel tricyclic and tetracyclic furoindoles: Biological evaluation as SAHA enhancer against neuroblastoma and breast cancer cells
dc.typeArticleen_US

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