Association Between Neuropathic Pain, Pregabalin Treatment, and Erectile Dysfunction

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dc.contributor.authorBozkurt, Mehtap
dc.contributor.authorGocmez, Cuneyt
dc.contributor.authorSoylemez, Haluk
dc.contributor.authorDaggulli, Mansur
dc.contributor.authorEm, Serda
dc.contributor.authorYildiz, Mehmet
dc.contributor.authorAtar, Murat
dc.date.accessioned2024-04-24T17:11:46Z
dc.date.available2024-04-24T17:11:46Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction. The pathophysiology of erectile dysfunction (ED) may be vasculogenic, hormonal, anatomical, neurogenic, drug-induced and/or psychogenic in origin. Neuropathic pain (NP) may facilitate ED, because it is frequently associated with anxiety, depression, and its drug, pregabalin, may also contribute ED. Aim. The objective of this study was to determine whether pregabalin treatment for patients with neuropathic pain promotes erectile dysfunction. Methods. The study sample consisted of a total of 102 male subjects that were subdivided into three groups. Group 1 patients (n = 31) had a pre-existing diagnosis of NP and was treated with 300 mg/day of pregabalin for at least 3 months. Group 2 patients (n = 34) were diagnosed with NP for at least 3 months; however, neither were they treated with pregabalin nor did they received physical therapy throughout the study. Lastly, healthy age-matched control subjects comprised group 3 (n = 37). Main Outcome Measures. Patients in all groups completed the International Index for Erectile Function (IIEF) questionnaire. Results. Mean age and mean body mass index did not differ significantly between each of the three groups. The cause of NP and the mean duration of having a diagnosis of NP did not differ significantly in groups 1 and 2. However, IIEF scores were significantly lower for group 1 when compared to group 2 in terms of erectile function, orgasmic function, overall satisfaction and total score. Yet groups 1 and 2 did not diverge significantly in the intercourse satisfaction and sexual desire scores. Overall IIEF scores for group 3 were significantly higher than those of group 2 except for mean erectile function scores. Conclusion. Taking pregabalin for the treatment of neuropathic pain poses an increased risk for developing ED in male patients. Thus, clinicians prescribing pregabalin to patients diagnosed with neuropathic pain should assess for ED before and during treatment with this medication.en_US
dc.identifier.doi10.1111/jsm.12458
dc.identifier.endpage1822en_US
dc.identifier.issn1743-6095
dc.identifier.issn1743-6109
dc.identifier.issue7en_US
dc.identifier.pmid24612455
dc.identifier.scopus2-s2.0-84903820799
dc.identifier.scopusqualityQ1
dc.identifier.startpage1816en_US
dc.identifier.urihttps://doi.org/10.1111/jsm.12458
dc.identifier.urihttps://hdl.handle.net/11468/17710
dc.identifier.volume11en_US
dc.identifier.wosWOS:000339071200022
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofJournal of Sexual Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeuropathic Painen_US
dc.subjectPregabalinen_US
dc.subjectErectile Dysfunctionen_US
dc.titleAssociation Between Neuropathic Pain, Pregabalin Treatment, and Erectile Dysfunctionen_US
dc.titleAssociation Between Neuropathic Pain, Pregabalin Treatment, and Erectile Dysfunction
dc.typeArticleen_US

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