Assessment of the underlying causes of the immune thrombocytopenia: Ten years experience

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dc.contributor.authorDal, Mehmet Sinan
dc.contributor.authorKarakus, Abdullah
dc.contributor.authorDal, Tuba
dc.contributor.authorAydin, Berrin Balik
dc.contributor.authorHattapoglu, Elif
dc.contributor.authorEkmen, Mehmet Onder
dc.contributor.authorUlas, Turgay
dc.date.accessioned2024-04-24T17:33:15Z
dc.date.available2024-04-24T17:33:15Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Immune thrombocytopenia (ITP) is an immune haematologic disorder causing platelet destruction mediated by anti-platelet antibodies. In this study we aimed to evaluate the clinical and laboratory variables of ITP patients in southeast of Turkey. Methods: In this retrospective study 167 ITP patients between 2005 and 2015 were evaluated. All patients were screened for immunological parameters including ANA (antinuclear antibodies), anti dsDNA (anti-double-strandedDNA), ACA(anti-cardiolipin) IgM and IgG, LA (lupus anticoagulants). All patients were screened for Helicobacter pylori, HBsAg (Hepatitis B surface antigen), anti-HCV (hepatitis C virus antibody), and anti-HIV 1/2 (HIV antibody) and brucellosis. Results: Among the patients, 50 (29.9%) patients were male, 117 (70.1%) were female. The age range of patients was 18-86 (mean 38.16+/-14). In 56 patients (33.5%) splenectomy was performed. 36 patients (21.6%) were positive for ANA, 5 (3%) were positive for anti dsDNA, 14 (8.4%) for ACA Ig G, and 14 (8.4%) patients for ACA IgM. LA was tested in 165 patients and 30 (18%) patients were positive for LA. Microbiologic evaluation was as follows: 16 patients (9.6%) were positive for HbsAg, 109 (65.3%) positive for Anti-HBs, 5 positive for anti-HCV (3%), 56 (33.5%) patients were positive for Helicobacter pylori antigen, 5 (2.9%) for Brucella and one patient was positive for anti-HIV 1/2. Conclusion: Immune thrombocytopenia patients have to be evaluated according to their demographic characteristics and laboratory results. Secondary causes of ITP were HIV, HCV, Helicobacter pylori, brucellosis, tuberculosis, and autoimmune diseases in our region. Management of ITP patients can change in different regions.en_US
dc.identifier.endpage1008en_US
dc.identifier.issn0030-9982
dc.identifier.issue7en_US
dc.identifier.pmid28770876
dc.identifier.scopus2-s2.0-85021104946
dc.identifier.scopusqualityQ3
dc.identifier.startpage1004en_US
dc.identifier.urihttps://hdl.handle.net/11468/20571
dc.identifier.volume67en_US
dc.identifier.wosWOS:000405942400007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPakistan Medical Assocen_US
dc.relation.ispartofJournal of The Pakistan Medical Association
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectImmune Thrombocytopeniaen_US
dc.subjectHelicobacter Pylorien_US
dc.subjectHepatitis C Virusen_US
dc.subjectBrucellaen_US
dc.subjectAntiphospholipid Antibodiesen_US
dc.titleAssessment of the underlying causes of the immune thrombocytopenia: Ten years experienceen_US
dc.titleAssessment of the underlying causes of the immune thrombocytopenia: Ten years experience
dc.typeArticleen_US

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