Predictive value of serum NT-proBNP levels in type 2 diabetic people with diabetic nephropathy

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dc.contributor.authorDanis, Ramazan
dc.contributor.authorOzmen, Sehmus
dc.contributor.authorArikan, Senay
dc.contributor.authorGokalp, Deniz
dc.contributor.authorAlyan, Omer
dc.date.accessioned2024-04-24T16:11:16Z
dc.date.available2024-04-24T16:11:16Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: The serum N-terminal fragment of pro brain natriuretic peptide (NT-proBNP) level in type 2 diabetic subjects with or without diabetic nephropathy (DN) is still unclear. We aimed to evaluate the relationship between serum NT-proBNP levels and different stages of diabetic nephropathy, and identify probable factors predicting serum NT-proBNP level. Subjects and methods: This cross-sectional study included 20 normoalbuminuric (Group-I), 28 microalbuminuric (Group-II), 20 macroalbuminuric type 2 diabetic patients (Group-III), and 20 healthy volunteers (Group-IV). Serum NT-proBNP levels were measured with highly sensitive and specific immunoassay. Results: Mean NT-proBNP levels were 32 +/- 55, 91 +/- 95, 331 +/- 297, 42 +/- 34 pg/ml for Groups I-IV, respectively. When patients with LVH were excluded, mean logNT-proBNP was still significantly higher in Group-III than all other groups. The three diabetic groups were similar in age, BMI, HbA1c, fasting serum glucose, and GFR. In a multivariate linear regression model, adjusting for factors significantly correlated with NT-proBNP levels, the patient group, presence of LVH, and hemoglobin remained as an independent predictor of serum NT-proBNP. These variables explained 68% of the variability of NT-proBNP (adjusted R-2 = 0.683). Conclusions: Mean serum NT-proBNP level of macroalbuminuric diabetic patients was higher than normoalbuminuric and microalbuminuric diabetic patients, and healthy control subjects even after exclusion of LVH. NT-proBNP may be a useful and predictive marker of diabetic nephropathy. (C) 2011 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.diabres.2011.09.029
dc.identifier.endpage316en_US
dc.identifier.issn0168-8227
dc.identifier.issn1872-8227
dc.identifier.issue3en_US
dc.identifier.pmid22018780
dc.identifier.scopus2-s2.0-84857234058
dc.identifier.scopusqualityQ1
dc.identifier.startpage312en_US
dc.identifier.urihttps://doi.org/10.1016/j.diabres.2011.09.029
dc.identifier.urihttps://hdl.handle.net/11468/15331
dc.identifier.volume95en_US
dc.identifier.wosWOS:000300638200008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofDiabetes Research and Clinical Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNt-Probnpen_US
dc.subjectDiabetic Nephropathyen_US
dc.subjectType 2 Diabetes Mellitusen_US
dc.titlePredictive value of serum NT-proBNP levels in type 2 diabetic people with diabetic nephropathyen_US
dc.titlePredictive value of serum NT-proBNP levels in type 2 diabetic people with diabetic nephropathy
dc.typeArticleen_US

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