Long term and excessive use of 900 MHz radiofrequency radiation alter microRNA expression in brain

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dc.contributor.authorDasdag, Suleyman
dc.contributor.authorAkdag, Mehmet Zulkuf
dc.contributor.authorErdal, Mehmet Emin
dc.contributor.authorErdal, Nurten
dc.contributor.authorAy, Ozlem Izci
dc.contributor.authorAy, Mustafa Ertan
dc.contributor.authorYilmaz, Senay Gorucu
dc.date.accessioned2024-04-24T17:20:30Z
dc.date.available2024-04-24T17:20:30Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose : We still do not have any information on the interaction between radiofrequency radiation (RF) and miRNA, which play paramount role in growth, differentiation, proliferation and cell death by suppressing one or more target genes. The purpose of this study was to bridge this gap by investigating effects of long-term 900 MHz mobile phone exposure on some of the miRNA in brain tissue. Materials and methods : The study was carried out on 14 Wistar Albino adult male rats by dividing them into two groups: Sham (n = 7) and exposure (n = 7). Rats in the exposure group were exposed to 900 MHz RF radiation for 3 h per day (7 days a week) for 12 months (one year). The same procedure was applied to the rats in the sham group except the generator was turned off. Immediately after the last exposure, rats were sacrificed and their brains were removed. rno-miR-9-5p, rno-miR-29a-3p, rno-miR-106b-5p, rno-miR-107 and rno-miR-125a-3p in brain were investigated in detail. Results : Results revealed that long-term exposure of 900 MHz RF radiation only decreased rno-miR107 (adjP* = 0 .045) value where the whole body (rms) SAR value was 0.0369 W/kg. However, our results indicated that other microRNA evaluated in this study was not altered by 900 MHz RF radiation. Conclusion : 900 MHz RF radiation can alter some of the miRNA, which, in turn, may lead to adverse effects. Therefore, further studies should be performed.en_US
dc.identifier.doi10.3109/09553002.2015.997896
dc.identifier.endpage311en_US
dc.identifier.issn0955-3002
dc.identifier.issn1362-3095
dc.identifier.issue4en_US
dc.identifier.pmid25529971
dc.identifier.scopus2-s2.0-84964284149
dc.identifier.scopusqualityQ2
dc.identifier.startpage306en_US
dc.identifier.urihttps://doi.org/10.3109/09553002.2015.997896
dc.identifier.urihttps://hdl.handle.net/11468/19095
dc.identifier.volume91en_US
dc.identifier.wosWOS:000351764200002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal of Radiation Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMobile Phonesen_US
dc.subject900 Mhz Rf Radiationen_US
dc.subjectMirnaen_US
dc.subjectBrainen_US
dc.subjectDiseasesen_US
dc.titleLong term and excessive use of 900 MHz radiofrequency radiation alter microRNA expression in brainen_US
dc.titleLong term and excessive use of 900 MHz radiofrequency radiation alter microRNA expression in brain
dc.typeArticleen_US

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