Severe pre-eclampsia complicated by HELLP syndrome alterations in the structure of the umbilical cord (morphometric and immunohistochemical study)

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dc.contributor.authorBalsak, Deniz
dc.contributor.authorTogrul, Cihan
dc.contributor.authorEkinci, Cenap
dc.contributor.authorCavus, Yunus
dc.contributor.authorTahaoglu, Ali Emre
dc.contributor.authorDeveci, Engin
dc.contributor.authorGul, Talip
dc.date.accessioned2024-04-24T17:07:45Z
dc.date.available2024-04-24T17:07:45Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the morphometric and immunohistochemistry in umbilical cords from patients with severe pre-eclampsia with and without haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome. The patient and control groups were similar according to baseline obstetric characteristics. White blood cell count in patients with HELLP syndrome and the control group was significantly increased among patients with HELLP syndrome (p < 0.001). Morphometric examination and endothelial core length were significantly different between the groups. In the umbilical cord cross-section of the HELLP group, endothelial cell degeneration in the vessel wall and basement membrane thickening were observed. In the muscle layer of blood vessels, the following disorders were found: increased collagen fibres in the muscle cell, hyperplasia and separation of muscle fibres as well as edema in the intermediate connective tissue. Immunohistochemical analysis showed that endothelial cells, basal membrane and fibroblast cells in the HELLP group expressed high levels of CD44. Vessel wall and amniotic epithelial basement membrane thickening were observed in the HELLP group. Matrix metalloproteinase 9 (MMP9) was expressed. Fibroblast and smooth muscle cells were fusiform and showed a positive reaction to immunohistochemical staining of alpha-actin smooth muscle.en_US
dc.identifier.doi10.1080/13102818.2014.991545
dc.identifier.endpage350en_US
dc.identifier.issn1310-2818
dc.identifier.issn1314-3530
dc.identifier.issue2en_US
dc.identifier.pmid26019650
dc.identifier.scopus2-s2.0-84925748127
dc.identifier.scopusqualityQ3
dc.identifier.startpage345en_US
dc.identifier.urihttps://doi.org/10.1080/13102818.2014.991545
dc.identifier.urihttps://hdl.handle.net/11468/16948
dc.identifier.volume29en_US
dc.identifier.wosWOS:000351840800016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnology & Biotechnological Equipment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlpha-Smooth Actinen_US
dc.subjectHellp Syndromeen_US
dc.subjectMmp9en_US
dc.subjectUmbilical Corden_US
dc.subjectCd44en_US
dc.titleSevere pre-eclampsia complicated by HELLP syndrome alterations in the structure of the umbilical cord (morphometric and immunohistochemical study)en_US
dc.titleSevere pre-eclampsia complicated by HELLP syndrome alterations in the structure of the umbilical cord (morphometric and immunohistochemical study)
dc.typeArticleen_US

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