Fructose-derived glycation and immune function: Effects on antigen binding in human IgG and lymphocytes

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dc.authoridakay, feryal/0000-0002-1075-926X
dc.contributor.authorAkay, Feryal
dc.contributor.authorInceoren, Nesrin
dc.contributor.authorNas, Cemal
dc.contributor.authorYokus, Beran
dc.contributor.authorKizil, Goksel
dc.contributor.authorKizil, Murat
dc.date.accessioned2025-02-22T14:09:03Z
dc.date.available2025-02-22T14:09:03Z
dc.date.issued2025
dc.departmentDicle Üniversitesien_US
dc.description.abstractDiabetes Mellitus (DM), one of the oldest known metabolic disorders, dates back to 3000 BC and continues to have a profound impact on health and the economy. Nutrition plays a critical role in managing diabetes and enhancing overall quality of life. It is also vital for immune system function, as well as in the prevention and treatment of aging-related diseases. A key factor contributing to the global rise in obesity is the excessive consumption of fructose/glucose (corn) syrup, which leads to various metabolic complications. Uncontrolled intake of carbohydrates, particularly sugars like fructose, triggers the Maillard Reaction, a chemical process that occurs between sugars and proteins, resulting in advanced glycation end-products (AGEs). This process is accelerated in diabetic patients due to hyperglycemia, leading to increased glycation of plasma proteins such as immunoglobulins, which play an essential role in the immune system. Studies show that individuals with Diabetes Mellitus experience a higher susceptibility to infections due to increased viral entry, impaired immune responses, reduced viral clearance, and dysregulated inflammatory cytokine production. In this study, human IgG proteins were glycated in vitro using fructose, simulating the damaging effects seen in diabetic conditions. A mixture containing antioxidants like glutathione, oleuropein, and selenium was prepared and incubated with the glycated IgG to assess its protective properties. Lymphocyte cells from healthy volunteers were also treated with fructose and subjected to similar experiments. Results demonstrated that fructose significantly compromises immune function by damaging key proteins, but the antioxidant mixture effectively mitigates this damage, offering a protective mechanism against glycation in the immune system.en_US
dc.description.sponsorship[22.004]en_US
dc.description.sponsorshipThis study was carried out as a thesis in the YOK 100/2000 Priority Thematic Area Biomaterials and Tissue Engineering doctoral program. Dicle University Scientific Research Project Coordinatorship was supported by the Ph.D. project numbered Science-22.004. All experiments were conducted in Dicle University, Faculty of Science, Department of Chemistry, Bioorganic Research Laboratory and Department of Biology, Cancer Reasearch Laboratory and DUSAM Research Laboratory, Diyarbak & imath;r, TURKEY.en_US
dc.identifier.doi10.1016/j.abb.2025.110315
dc.identifier.issn0003-9861
dc.identifier.issn1096-0384
dc.identifier.pmid39842560en_US
dc.identifier.scopus2-s2.0-85215541579en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.abb.2025.110315
dc.identifier.urihttps://hdl.handle.net/11468/29775
dc.identifier.volume765en_US
dc.identifier.wosWOS:001408340900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofArchives of Biochemistry and Biophysicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectImmunityen_US
dc.subjectType II diabetesen_US
dc.subjectAntioxidanten_US
dc.subjectFructoseen_US
dc.subjectImmunoglobulin Gen_US
dc.subjectAGEsen_US
dc.titleFructose-derived glycation and immune function: Effects on antigen binding in human IgG and lymphocytesen_US
dc.typeArticleen_US

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