Assessment of inflammation biomarkers in diabetic macular edema treated with intravitreal dexamethasone implant
[ X ]
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Mary Ann Liebert, INC
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: To evaluate inflammation biomarkers in diabetic macular edema (DME) treated with intravitreal dexamethasone implant (Ozurdex(R)).
Methods: This retrospective single-center study investigated 64 eyes of 64 patients with DME who were nonresponsive to prior antivascular endothelial growth factor and treated with intravitreal Ozurdex. The neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/lymphocyte ratio were calculated. Visual acuity and optical coherence tomography markers, including hyper-reflective dots and subretinal fluid (SRF), were determined, and central retinal thickness was also evaluated monthly for 3 months.
Results: The average age was 64.06 +/- 7.81 (48-84) years. The baseline NLR and MLR were significantly higher in patients with better visual outcomes (P = 0.029 and P = 0.048, respectively). Better anatomical outcomes were observed in the presence of SRF (P = 0.027). No significant differences were observed in the rates of the presence of SRF and hyper-reflective points about the better functional outcome (P > 0.05).
Conclusions: SRF as an imaging biomarker, and NLR and MLR as blood biomarkers, stand out as markers of inflammation and were found to be associated with better response to Ozurdex implantation in DME.
Açıklama
WOS:000648054200001
PMID: 33961524
PMID: 33961524
Anahtar Kelimeler
Biomarker, Inflammation, Hyper-reflective dots, Neutrophil, Lymphocyte ratio, Diabetic macular edema
Kaynak
Journal of Ocular Pharmacology and Therapeutics
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
37
Sayı
7
Künye
Vural, E. ve Hazar, L. (2021). Assessment of inflammation biomarkers in diabetic macular edema treated with intravitreal dexamethasone implant. Journal of Ocular Pharmacology and Therapeutics, 37(7), 430-437. https://doi.org/10.1089/jop.2020.0130
