Clinical features, diagnosis and treatment outcomes of Cushing's disease in children: A multicenter study

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dc.authorid0000-0002-1874-7570en_US
dc.authorid0000-0002-0488-6377en_US
dc.authorid0000-0003-3974-2872en_US
dc.authorid0000-0002-1684-1053en_US
dc.authorid0000-0003-0594-8741en_US
dc.contributor.authorTarçın, Gürkan
dc.contributor.authorÇatlı, Gönül
dc.contributor.authorÇetinkaya, Semra
dc.contributor.authorEren, Erdal
dc.contributor.authorKardelen, Aslı Derya
dc.contributor.authorAkıncı, Ayşehan
dc.contributor.authorYıldırım, Ruken
dc.date.accessioned2024-04-16T11:13:15Z
dc.date.available2024-04-16T11:13:15Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractObjective: Since Cushing's disease (CD) is less common in the paediatric age group than in adults, data on this subject are relatively limited in children. Herein, we aim to share the clinical, diagnostic and therapeutic features of paediatric CD cases. Design: National, multicenter and retrospective study. Patients: All centres were asked to complete a form including questions regarding initial complaints, physical examination findings, diagnostic tests, treatment modalities and follow-up data of the children with CD between December 2015 and March 2017. Measurements: Diagnostic tests of CD and tumour size. Results: Thirty-four patients (M:F = 16:18) from 15 tertiary centres were enroled. The most frequent complaint and physical examination finding were rapid weight gain, and round face with plethora, respectively. Late-night serum cortisol level was the most sensitive test for the diagnosis of hypercortisolism and morning adrenocorticotropic hormone (ACTH) level to demonstrate the pituitary origin (100% and 96.8%, respectively). Adenoma was detected on magnetic resonance imaging (MRI) in 70.5% of the patients. Transsphenoidal adenomectomy (TSA) was the most preferred treatment (78.1%). At follow-up, 6 (24%) of the patients who underwent TSA were reoperated due to recurrence or surgical failure. Conclusions: Herein, national data of the clinical experience on paediatric CD have been presented. Our findings highlight that presenting complaints may be subtle in children, the sensitivities of the diagnostic tests are very variable and require a careful interpretation, and MRI fails to detect adenoma in approximately one-third of cases. Finally, clinicians should be aware of the recurrence of the disease during the follow-up after surgery.en_US
dc.identifier.citationTarçın, G., Çatlı, G., Çetinkaya, S., Eren, E., Kardelen, A. D., Akıncı, A. ve diğerleri. (2023). Clinical features, diagnosis and treatment outcomes of Cushing's disease in children: A multicenter study. Clinical Endocrinology, 100(1), 19-28.en_US
dc.identifier.doi10.1111/cen.14980
dc.identifier.endpage28en_US
dc.identifier.issn0300-0664
dc.identifier.issue1en_US
dc.identifier.pmid37814958
dc.identifier.scopus2-s2.0-85173788943
dc.identifier.scopusqualityQ2
dc.identifier.startpage19en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/cen.14980
dc.identifier.urihttps://hdl.handle.net/11468/13883
dc.identifier.volume100en_US
dc.identifier.wosWOS:001083355900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYıldırım, Ruken
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofClinical Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildrenen_US
dc.subjectCrooke's hyaline changeen_US
dc.subjectCushing's diseaseen_US
dc.subjectHypercortisolismen_US
dc.subjectTranssphenoidal adenomectomyen_US
dc.titleClinical features, diagnosis and treatment outcomes of Cushing's disease in children: A multicenter studyen_US
dc.titleClinical features, diagnosis and treatment outcomes of Cushing's disease in children: A multicenter study
dc.typeArticleen_US

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