Potential role of increasing number of sections in frozen section diagnosis of ovarian tumors

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dc.contributor.authorAyhan, Ali
dc.contributor.authorOzler, Ali
dc.contributor.authorDursun, Polat
dc.contributor.authorHaberal, A. Nihan
dc.date.accessioned2024-04-24T17:37:47Z
dc.date.available2024-04-24T17:37:47Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: To assess the accuracy of intraoperative frozen section of ovarian tumours at our institution and to identify the possible reasons for misdiagnosis. Study Design: Between January 2002 and August 2013, a total of 684 patients were included in the study. Frozen section diagnosis was compared with the final paraffin section diagnosis as the gold standard. The sensitivity, specificity, and positive and negative predictive values of frozen-section diagnosis were calculated for benign, borderline and malignant tumours. Clinicopathological parameters influenced by misdiagnosis were evaluated performing multivariate logistic regression analysis. Results: The overall accuracy was detected as 96.1%. Frozen-section diagnoses of 26 patients (3.8%) showed discordance. The specificity (99.7%) and PPV (99.4%) of frozen-section diagnosis was highest in the malignant category. In BOTs, diagnostic agreement was observed in 57 of 70 (81.4%) cases. The PPV (81.4%) was lowest for these patients. Tumour diameter of >= 10 cm (OR [95% CI]= 3.0 [1.1 to 8.2]; P=0.030) and mucinous histology (OR [95% CI]. 2.5 [1.0 to 6.2]; P=0.042) were significant predictors of misdiagnosis. With the increase in the number of sections, the accuracy rate of frozen section diagnosis was decreased. While not statistically significant (p=0.361). Conclusion: The number of sections is increased parallel to increase in tumor diameters. On the contrary, the diagnostic accuracy was no significantly increased with an increase in the number of sections. This discrepancy may be associated with falling tumor size per frozen section. A prospective study based on a certain tumour diameter per frozen section may better demonstrate the positive effect of the number of sections.en_US
dc.identifier.endpage250en_US
dc.identifier.issn1359-4117
dc.identifier.issn1533-869X
dc.identifier.issue4en_US
dc.identifier.pmid27849334
dc.identifier.scopus2-s2.0-84995653356
dc.identifier.scopusqualityQ4
dc.identifier.startpage245en_US
dc.identifier.urihttps://hdl.handle.net/11468/21182
dc.identifier.volume11en_US
dc.identifier.wosWOS:000387093900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherOld City Publishing Incen_US
dc.relation.ispartofJournal of Experimental Therapeutics and Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titlePotential role of increasing number of sections in frozen section diagnosis of ovarian tumorsen_US
dc.titlePotential role of increasing number of sections in frozen section diagnosis of ovarian tumors
dc.typeArticleen_US

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