Biomechanical properties of osteoporotic rat femurs after different hormonal treatments: genistein, estradiol, and estradiol/progesterone

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dc.contributor.authorAzboy, Ibrahim
dc.contributor.authorOzkaya, Mustafa
dc.contributor.authorDemir, Teyfik
dc.contributor.authorDemirtas, Abdullah
dc.contributor.authorArslan, Arslan Kagan
dc.contributor.authorOzkul, Emin
dc.contributor.authorAkcan, Adnan
dc.date.accessioned2024-04-24T16:24:07Z
dc.date.available2024-04-24T16:24:07Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction: The purpose of the study is to compare the effects of genistein, estradiol, estradiol/progesterone combination on the bone mineral density and biomechanical properties of ovariectomized rats' bone. Methods: 50 female adult Sprague-Dawley rats were divided into five groups. Bilateral ovaeriectomy were performed in all groups except the sham-operated group. Groups were a sham-operated group and a control group (water was given), estradiol treated group (17-b estradiol 0.015 mg/kg per day), genistein treated group (genistein 10 mg/kg per day), and an estradiol/progesterone combination group (17-b estradiol 0.015 mg/kg plus drosperinone 0.028 mg/kg per day). The water or hormones were implemented in relevant groups for eight weeks by orogasthric catheter. The bone mineral density and biomechanical properties of the femur were analyzed. Results: Genistein, estradiol, and estradiol/progesterone groups increased bone mineral density significantly compared to the control group. In diaphysis and metaphysis bending test, all groups had higher peak load values than the control group. There were statistically significant differences between the estrogen/progesterone group and control group in diaphysis bending with regard to peak load. There were statistically significant differences between the estradiol and control groups in metaphysis bending with regard to peak load. In axial rotation test, all groups had higher peak torque values than the control groups. Conclusions: Genistein, estradiol and estrogen/progesterone combination improved the biomechanical properties of the ovariectomized rat bone. Genistein which has less side effects may be considered as an alternative in the treatment of postmenopausal osteoporosis.en_US
dc.identifier.doi10.1051/sicotj/2016016
dc.identifier.issn2426-8887
dc.identifier.pmid27194109
dc.identifier.scopus2-s2.0-85012086094
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1051/sicotj/2016016
dc.identifier.urihttps://hdl.handle.net/11468/16511
dc.identifier.volume2en_US
dc.identifier.wosWOS:000405864400024
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherEdp Sciences S Aen_US
dc.relation.ispartofSicot-J
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOsteoporosisen_US
dc.subjectRat Femuren_US
dc.subjectBiomechanicen_US
dc.subjectGenisteinen_US
dc.subjectEstradiolen_US
dc.titleBiomechanical properties of osteoporotic rat femurs after different hormonal treatments: genistein, estradiol, and estradiol/progesteroneen_US
dc.titleBiomechanical properties of osteoporotic rat femurs after different hormonal treatments: genistein, estradiol, and estradiol/progesterone
dc.typeArticleen_US

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