Decreased Serum Sulphydryl Levels as a Sign of Increased Oxidative Stress in Generalized Anxiety Disorder

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dc.contributor.authorKaya, Mehmet Cemal
dc.contributor.authorBez, Yasin
dc.contributor.authorKarababa, Ibrahim Fatih
dc.contributor.authorEmhan, Ali
dc.contributor.authorAksoy, Nurten
dc.contributor.authorBulut, Mahmut
dc.contributor.authorGunes, Mehmet
dc.date.accessioned2024-04-24T17:24:33Z
dc.date.available2024-04-24T17:24:33Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective In recent years, many published studies have focused on the relationship between oxidative stress and psychiatric disorders. However, studies in generalized anxiety disorder (GAD) are few despite relatively high prevalence rates. In an attempt to fill this gap in the literature we aimed to measure serum levels of free sulphydryl, an important member of antioxidant defense mechanisms, of the patients with GAD. Methods A total of 35 (23 female, 12 male) GAD patients without any other co-morbid medical or psychiatric disorder and 35 (23 female, 12 male) healthy controls have been included in the study. Disease severity of the patients were quantified by using the Hamilton Anxiety Rating Scale (HAM-A). Serum free sulphydryl group levels of patients and healthy controls were measured in an appropriate way. Results Mean level of serum sulphydryl groups was significantly lower in the patient group. There was a negative correlation between their level and the disease duration. However, they did not show any significant correlation with the disease severity. Conclusion Decreased serum sulphydryl level observed in pure GAD patients suggests an increased oxidative stress in these patients. Well designed future researches are needed to replicate our findings and to test the implications of the present study.en_US
dc.identifier.doi10.4306/pi.2013.10.3.281
dc.identifier.endpage285en_US
dc.identifier.issn1738-3684
dc.identifier.issn1976-3026
dc.identifier.issue3en_US
dc.identifier.pmid24302952
dc.identifier.scopus2-s2.0-84885822768
dc.identifier.scopusqualityQ2
dc.identifier.startpage281en_US
dc.identifier.urihttps://doi.org/10.4306/pi.2013.10.3.281
dc.identifier.urihttps://hdl.handle.net/11468/19735
dc.identifier.volume10en_US
dc.identifier.wosWOS:000325666600011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKorean Neuropsychiatric Assocen_US
dc.relation.ispartofPsychiatry Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGeneralized Anxiety Disorderen_US
dc.subjectSulphydrylen_US
dc.subjectOxidative Stress And Antioxidanten_US
dc.titleDecreased Serum Sulphydryl Levels as a Sign of Increased Oxidative Stress in Generalized Anxiety Disorderen_US
dc.titleDecreased Serum Sulphydryl Levels as a Sign of Increased Oxidative Stress in Generalized Anxiety Disorder
dc.typeArticleen_US

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