Hypothalamic-pituitary-gonadal axis and cortisol in young women with primary fibromyalgia: the potential roles of depression, fatigue, and sleep disturbance in the occurrence of hypocortisolism

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dc.contributor.authorGur, A
dc.contributor.authorCevik, R
dc.contributor.authorSarac, AJ
dc.contributor.authorColpan, L
dc.contributor.authorEm, S
dc.date.accessioned2024-04-24T17:11:58Z
dc.date.available2024-04-24T17:11:58Z
dc.date.issued2004
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: To investigate abnormalities of the hypothalamic-pituitary-gonadal (HPG) axis and cortisol concentrations in young women with primary fibromyalgia ( FM); and to determine whether depression, fatigue, and sleep disturbance affect these hormones. Methods: Follicle stimulating hormone (FSH), luteinising hormone (LH), oestradiol, progesterone, prolactin, and cortisol concentrations in 63 women with FM were compared with those in 38 matched healthy controls; all subjects aged <35 years. The depression rate was assessed by the Beck Depression Inventory (BDI) and patients with high and low BDI scores were compared. Additionally, patients were divided according to sleep disturbance and fatigue and compared both with healthy controls and within the group. Results: No significant differences in FSH, LH, oestradiol, prolactin, and progesterone levels were found between patients with FM and controls, but cortisol levels were significantly lower in patients than in controls (p < 0.05). Cortisol levels in patients with high BDI scores, fatigue, and sleep disturbance were significantly lower than in controls (p < 0.05). Correlation between cortisol levels and number of tender points in all patients was significant (r = -0.32, p < 0.05). Conclusion: Despite low cortisol concentrations in young women with FM, there is no abnormality in HPG axis hormones. Because fatigue, depression rate, sleep disturbance, and mean age of patients affect cortisol levels, these variables should be taken into account in future investigations.en_US
dc.identifier.doi10.1136/ard.2003.014969
dc.identifier.endpage1506en_US
dc.identifier.issn0003-4967
dc.identifier.issn1468-2060
dc.identifier.issue11en_US
dc.identifier.pmid15479904
dc.identifier.scopus2-s2.0-7244260376
dc.identifier.scopusqualityQ1
dc.identifier.startpage1504en_US
dc.identifier.urihttps://doi.org/10.1136/ard.2003.014969
dc.identifier.urihttps://hdl.handle.net/11468/17802
dc.identifier.volume63en_US
dc.identifier.wosWOS:000224412800026
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBmj Publishing Groupen_US
dc.relation.ispartofAnnals of The Rheumatic Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword]en_US
dc.titleHypothalamic-pituitary-gonadal axis and cortisol in young women with primary fibromyalgia: the potential roles of depression, fatigue, and sleep disturbance in the occurrence of hypocortisolismen_US
dc.titleHypothalamic-pituitary-gonadal axis and cortisol in young women with primary fibromyalgia: the potential roles of depression, fatigue, and sleep disturbance in the occurrence of hypocortisolism
dc.typeArticleen_US

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