Epidemiological features of primary glomerular disease in Turkey: a multicenter study by the Turkish Society of Nephrology Glomerular Diseases Working Group
Yükleniyor...
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
BioMed Central Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Abstract
Background: The largest data on the epidemiology of primary glomerular diseases (PGDs) are obtained from the
databases of countries or centers. Here, we present the extended results of the Primary Glomerular Diseases Study
of the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group.
Methods: Data of patients who underwent renal biopsy and received the diagnosis of PGD were recorded in the
database prepared for the study. A total of 4399 patients from 47 centers were evaluated between May 2009 and
May 2019. The data obtained at the time of kidney biopsy were analyzed. After the exclusion of patients without
light microscopy and immunofluorescence microscopy findings, a total of 3875 patients were included in the study.
Results: The mean age was 41.5 ± 14.9 years. 1690 patients were female (43.6%) and 2185 (56.3%) were male.
Nephrotic syndrome was the most common biopsy indication (51.7%). This was followed by asymptomatic urinary
abnormalities (18.3%) and nephritic syndrome (17.8%). The most common PGD was IgA nephropathy (25.7%)
followed by membranous nephropathy (25.6%) and focal segmental glomerulosclerosis (21.9%). The mean total
number of glomeruli per biopsy was 17 ± 10. The mean baseline systolic blood pressure was 130 ± 20 mmHg and
diastolic blood pressure was 81 ± 12 mmHg. The median proteinuria, serum creatinine, estimated GFR, and mean
albumin values were 3300 (IQR: 1467–6307) mg/day, 1.0 (IQR: 0.7–1.6) mg/dL, 82.9 (IQR: 47.0–113.0) mL/min and 3.2 ± 0.9 g/dL, respectively.
Conclusions: The distribution of PGDs in Turkey has become similar to that in other European countries. IgA
nephropathy diagnosed via renal biopsy has become more prevalent compared to membranous nephropathy.
Keywords: Epidemiology, Glomerulonephritis, Kidney biopsy, Primary glomerular diseases; the Turkish Society of
Nephrology glomerular diseases (TSN-GOLD) working group, Turkish Society of Nephrology
Açıklama
WOS:000589687100001
PMID: 33189135
PMID: 33189135
Anahtar Kelimeler
Epidemiology, Glomerulonephritis, Kidney biopsy, Primary glomerular diseases, the Turkish Society of Nephrology glomerular diseases (TSN-GOLD) working group, Turkish Society of Nephrology
Kaynak
BMC Nephrology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
21
Sayı
1
Künye
Türkmen, A., Şumnu, A., Cebeci, E., Yazıcı, H., Eren, N., Seyahi, N. ve diğerleri. (2020). Epidemiological features of primary glomerular disease in Turkey: a multicenter study by the Turkish Society of Nephrology Glomerular Diseases Working Group. BMC Nephrology, 21(1), 1-11
