Determination of dermatology life quality index, and serum C-reactive protein and plasma interleukin-6 levels in patients with chronic urticaria

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dc.contributor.authorUcmak, Derya
dc.contributor.authorAkkurt, Meltem
dc.contributor.authorToprak, Gulten
dc.contributor.authorYesilova, Yavuz
dc.contributor.authorTuran, Enver
dc.contributor.authorYildiz, Ismail
dc.date.accessioned2024-04-24T17:24:52Z
dc.date.available2024-04-24T17:24:52Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction: C-reactive protein (CRP) and interleukin-6 (IL-6), which is one of its most important simulators, were determined in great amounts in the sera of patients with chronic urticaria (CU). Aim: To determine the levels of IL-6 in patients with urticaria, and evaluate its relationship with urticaria activity scores and Dermatology Life Quality Index (DLQI). Material and methods: Fifty-three patients with CU were included in the study successively by determining their urticaria activity scores (0-3) and DLQI (0-5). The CRP and IL-6 were measured by immune assay methods. Thirty-two healthy subjects were included as a control group. Results: Serum levels of IL-6 and CRP were significantly higher in patients with CU compared to healthy controls (p < 0.001, p = 0.026 respectively). There was a statistically significant correlation among urticaria activity scores and IL-6 and CRP concentration (p = 0.004, p = 0.042). This correlation was more significant in patients who had moderate and severe disease activity scores than in those who had mild disease activity score (p < 0.001, p < 0.001, respectively). There was a statistically significant association between DLQI and IL-6 (p = 0.025). This correlation was very significant in patients who had severe and very severe disease activity scores (p < 0.001, p < 0.001, respectively). DLQI scores and serum levels of IL-6 were significantly different in the very severe group compared to healthy controls (p = 0.024). Conclusions: The levels of CRP and IL-6 are increased in patients with CU. A relationship of DLQI and urticaria activity scores with CRP and IL-6 was found. These findings support the relationship between the inflammatory process in CU and the clinical findings.en_US
dc.identifier.doi10.5114/pdia.2013.35615
dc.identifier.endpage151en_US
dc.identifier.issn1642-395X
dc.identifier.issue3en_US
dc.identifier.pmid24278066
dc.identifier.scopus2-s2.0-84880128329
dc.identifier.scopusqualityQ2
dc.identifier.startpage146en_US
dc.identifier.urihttps://doi.org/10.5114/pdia.2013.35615
dc.identifier.urihttps://hdl.handle.net/11468/19863
dc.identifier.volume30en_US
dc.identifier.wosWOS:000323095900004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofPostepy Dermatologii I Alergologii
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic Urticariaen_US
dc.subjectDermatology Life Quality Indexen_US
dc.subjectInterleukin-6en_US
dc.titleDetermination of dermatology life quality index, and serum C-reactive protein and plasma interleukin-6 levels in patients with chronic urticariaen_US
dc.titleDetermination of dermatology life quality index, and serum C-reactive protein and plasma interleukin-6 levels in patients with chronic urticaria
dc.typeArticleen_US

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