Myocardial infarction and venous thrombosis in a 42-year old woman with heterozygous methylenetetrahydrofolate reductase (MTHRF) gene mutation, hyperhomocysteinemia, and protein C deficiency

Özet

Objective: Hyperhomocysteinemia and protein C deficiency have synergistic effect on the onset of thrombotic disease. Methods: We report a 42-year old woman with myocardial infarction and venous thrombosis in whom recognition of heterozygous MTHRF gene mutation, hyperhomocysteinemia, and protein C deficiency. Results: The patient was treated successfully with coronary artery bypass graft surgery and systemic anticoagulation. Conclusions: Our report emphasize that a combined hyperhomocysteinemia, and protein C deficiency may be a high risk factor for arterial and venous thromboembolic events in young adults. These patients might be candidates for indefinite anticoagulation.

Açıklama

Anahtar Kelimeler

Hyperhomocysteinemia, Mthrf gene mutation, Protein C deficiency

Kaynak

International Journal of Cardiology

WoS Q Değeri

Scopus Q Değeri

Q1

Cilt

117

Sayı

3

Künye

Çakır, Ö., Ayyıldız, O., Göz, M., Şit, D. ve Eren, N. (2007). Myocardial infarction and venous thrombosis in a 42-year old woman with heterozygous methylenetetrahydrofolate reductase (MTHRF) gene mutation, hyperhomocysteinemia, and protein C deficiency. International Journal of Cardiology, 117(3), e98-e100.