A biochemical approach for hedysarum candidissimum from Turkey: Screening phytochemicals, evaluation of biological activites, and molecular docking study

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dc.contributor.authorAltay, Ahmet
dc.contributor.authorYeniçeri, Esma
dc.contributor.authorTaslimi, Parham
dc.contributor.authorTok, Tuğba Taşkın
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorKöksal, Ekrem
dc.contributor.orcid0000-0002-3171-0633
dc.contributor.orcid0000-0002-0064-8400
dc.contributor.orcid0000-0002-4090-7227
dc.contributor.orcid0000-0002-1026-972X
dc.contributor.orcid0000-0001-8120-8900
dc.date.accessioned2024-04-24T15:59:21Z
dc.date.available2024-04-24T15:59:21Z
dc.date.issued2022
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalıen_US
dc.description.abstractThis study was designed to screen the phytochemical composition and investigate the biological activities of Hedysarum candidissimum extracts and also support the results with molecular docking studies. LC/MS/MS analysis revealed the presence of 22 phytochemical constituents (mainly phenolic acids, flavonoids, and flavonoid glycosides) in the plant structure. The methanol extract exhibited the strongest antioxidant activity among all the extracts with its strong DPPH radical scavenging and iron reducing capacity, as well as high phenolic and flavonoid contents. Additionally, it was found to be the most promising acetylcholinesterase (AChE: IC50: 93.26 mu g/mL) and alpha-glycosidase (AG: IC50: 28.57 mu g/mL) inhibitory activities, supported by the major phenolics of the species through in silico studies. Ethyl acetate extract had the strongest cytotoxic effect on HT-29 (IC50: 63.03 mu g/mL) and MDA-MB-453 (IC50: 95.36 mu g/mL) cancer cell lines. Both extracts exhibited considerable apoptotic and anti-migrative effects on HT-29 cells. The investigations provide phyto-analytical and bio-pharmacological results which can be extended by in vivo studies in the future.en_US
dc.description.sponsorshipErzincan University Scientific Research Projects Coordination Commission (EU-BAP) [2020-736]en_US
dc.description.sponsorshipThis work was financially supported by grants from Erzincan University Scientific Research Projects Coordination Commission (EU-BAP) (Project No: 2020-736). The authors thank Esin Ak Yalcin and the research group for technical assistance. The authors also thank Prof.Dr. Ali Kandemir for plant collection and species identification.en_US
dc.identifier.citationAltay, A., Yeniçeri, E., Taslimi, P., Tok, T. T., Yılmaz, M. A. ve Köksal, E. (2022). A biochemical approach for hedysarum candidissimum from Turkey: Screening phytochemicals, evaluation of biological activites, and molecular docking study. Chemistry and Biodiversity, 19(9), 1-18.
dc.identifier.doi10.1002/cbdv.202200348
dc.identifier.endpage18
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue9en_US
dc.identifier.pmid36045318
dc.identifier.scopus2-s2.0-85137186777
dc.identifier.scopusqualityQ3
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1002/cbdv.202200348
dc.identifier.urihttps://hdl.handle.net/11468/14004
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/cbdv.202200348
dc.identifier.volume19en_US
dc.identifier.wosWOS:000847914700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistry & Biodiversity
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHedysarum candidissimumen_US
dc.subjectPhytochemicalsen_US
dc.subjectBiologic activityen_US
dc.subjectMolecular dockingen_US
dc.titleA biochemical approach for hedysarum candidissimum from Turkey: Screening phytochemicals, evaluation of biological activites, and molecular docking studyen_US
dc.titleA biochemical approach for hedysarum candidissimum from Turkey: Screening phytochemicals, evaluation of biological activites, and molecular docking study
dc.typeArticleen_US

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