EVALUATION OF SERUM LEVELS OF OSTEOPONTIN AND BONE SIALOPROTEIN IN FEMALE PATIENTS WITH TENDINOPATHY

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dc.contributor.authorHira, Serdar
dc.contributor.authorTamam, Cuneyt
dc.contributor.authorDemirpek, Ugur
dc.contributor.authorGem, Mehmet
dc.date.accessioned2024-04-24T17:24:41Z
dc.date.available2024-04-24T17:24:41Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: The pathogenesis of tendinopathy remains unclear. Small integrin-binding ligand N-linked glycoproteins (SIBLING), a family of non-collagenous proteins including osteopontin (OPN) and bone sialoprotein (BSP), were initially thought to be limited to mineralized tissue, but recent studies have reported that they are more widely distributed and are expressed in non-mineralized tissues. The aim of this study was to investigate relationships between serum OPN and BSP levels and tendinopathy disease. Material and Method: 39 female tendinopathy patients and 39 female healthy volunteers were recruited for this prospective observational study. Serum OPN and BSP levels were measured using enzyme-linked immunosorbent assay. We also measured body mass index and erythrocyte sedimentation rate (ESR), white blood cells (WBC), and neutrophil-lymphocyte ratio (NLR). Results: There were no significant differences in serum BSP levels between the two groups (41.83 +/- 52.03 vs. 53.64 +/- 53.06 ng/mL, p=0.276). There were also no significant differences in serum OPN levels between the two groups (57.37 +/- 21.61 vs. 77.72 +/- 72.14 ng/mL, p=0.363). There were no significant differences in WBC, NLR, and ESR values between the two groups (p=0.897, p=0.795, p=0.405, respectively). There was no correlation between serum BSP levels and OPN, WBC, NLR, and ESR levels in the patient group. Patients with tendinopathy had a negative correlation between serum OPN levels and NLR levels. Discussion: The results of this study have indicated that BSP and OPN levels are not involved in the pathogenesis of tendinopathy.en_US
dc.identifier.doi10.4328/JCAM.4854
dc.identifier.endpage274en_US
dc.identifier.issn1309-0720
dc.identifier.issn1309-2014
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85016620169
dc.identifier.scopusqualityN/A
dc.identifier.startpage271en_US
dc.identifier.urihttps://doi.org/10.4328/JCAM.4854
dc.identifier.urihttps://hdl.handle.net/11468/19790
dc.identifier.volume8en_US
dc.identifier.wosWOS:000435654000004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherDerman Medical Publen_US
dc.relation.ispartofJournal of Clinical and Analytical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTendinopathyen_US
dc.subjectBone Sialoproteinen_US
dc.subjectOsteopontinen_US
dc.subjectSibling Familyen_US
dc.titleEVALUATION OF SERUM LEVELS OF OSTEOPONTIN AND BONE SIALOPROTEIN IN FEMALE PATIENTS WITH TENDINOPATHYen_US
dc.titleEVALUATION OF SERUM LEVELS OF OSTEOPONTIN AND BONE SIALOPROTEIN IN FEMALE PATIENTS WITH TENDINOPATHY
dc.typeArticleen_US

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